STUDY OF MOLECULAR DOCKING OF ANTIHIPERGLICEMIC COMPOUNDS ON KELOR (Moringa oleifera) ON RECEPTOR PPAR-γ AS THERAPY FOR TYPE 2 DIABETES MELLITUS

Abstrak

Diabetes mellitus (DM) is a degenerative disease caused either when the pancreas can not produce enough
insulin or when the body can not use effectively produced insulin. Kelor (Moringa oleifera) has been widely
used by the community as a food ingredient as well as the prevention and treatment of diabetes. In the leaves
contain compounds that can act as antihiperglikemik drug. One of the receptors that play a role in the treatment
of diabetes is Peroxisome Proliferator-Activator Receptor-Gamma (PPAR-γ). The in silico method has been
developed and widely used in developing pharmacological hypotheses and testing. This study aims to determine
the interaction between PPAR-γ and Moringa oleifera compounds. In this study, the interactions between the
compounds in the Kelor leaf as ligand, with PPAR-γ observed using PyRx software, which is a program that can
tether the ligand molecule to the receptor macromolecule. Then visualized using Pymol and PLIP. The results
show that the compounds exhibit a bond energy bond range between -8.0 to -4.7. Among the three compounds is
known that Quercetin has the greatest potential as antihyperglycemic seen from the bond energy value is -8,0,
the number of hydrogen bonds are as much as 3, the shortest distance of the bonds is 1,94 and RMSD is 1,372.
In this study also expected to find new drugs for the treatment of type 2 diabetes mellitus