HYDROGEL UNTUK RECCURENT APHTHOUS STOMATITIS

Nia Yuniarsih, Muchtaridi Muchtaridi, Nasrul Wathoni

Abstrak


Recurrent Aphthous Stomatitis merupakan penyakit ulseratif mukosa mulut yang belum diketahui dengan pasti penyebabnya hingga saat ini, sehingga pengobatan yang diberikan hanya untuk mengurangi rasa sakit dan memperkecil ukuran ulkus. Formulasi yang dimodifikasi memberikan cara yang cukup efektif untuk mengatasi cepat atau tidaknya obat larut atau terbawa oleh cairan mukosa mulut sehingga dapat memperpanjang kontak obat dengan ulkus. Dalam pembuatan sediaan lepas terkendali, polimer memiliki peran penting. Ada  banyak polimer yang dapat digunakan untuk kontrol pelepasan obat dan membutuhkan pertimbangan fisiologis dan fisikokimia. Polimer dapat digunakan sebagai hidrogel film yang dirancang untuk memisahkan lesi mukosa dari lingkungan rongga mulut, dan dengan demikian mengurangi resiko terbawanya obat oleh air liur dari pengobatan lokal yang diberikan. Aplikasi ini dapat meningkatkan durasi kontak antara zat aktif dan lesi sehingga meningkatkan efektivitas terapi, mengurangi ketidaknyamanan  pasien dan membawa obat  lebih cepat dari pada gel. Artikel ini bertujuan untuk melihat berbagai macam polimer yang dapat digunakan dalam sediaan hidrogel untuk pengobatan RAS

Teks Lengkap:

PDF

Referensi


Abdullah, E., Idris, A., & Saparon, A. (2017). Papr reduction using scs-slm technique in stfbc mimo-ofdm. ARPN Journal of Engineering and Applied Sciences, 12(10), 3218–3221. https://doi.org/10.1111/ijlh.12426

Article, R. (2015). Guideline for the Diagnosis and Treatment of Recurrent Aphthous Stomatitis for Dental Practitioners, 7(November 2014), 74–80.

Aslani, A. (2018). Dental Research Journal, 484–493.

Chavan, M., Jain, H., Diwan, N., Khedkar, S., Shete, A., & Durkar, S. (2012). Recurrent aphthous stomatitis : a review. https://doi.org/10.1111/j.1600-0714.2012.01134.x

Du, Q., Ni, S., Guo, L., Song, W., Zhao, K., Liu, N., … Tan, Q. (2018). ScienceDirect Effects of Zingiber officinalis ( WILLD .) ROSC . Membranes on minor recurrent aphthous stomatitis : A randomized pragmatic trial. Journal of Traditional Chinese Medical Sciences, 2–7. https://doi.org/10.1016/j.jtcms.2018.02.004

Gayathri, R., & Anuradha, V. (2018). EVALUATION OF ANTIBACTERIAL ACTIVITY OF ACETONE MACE EXTRACT ( Myristica fragrans Houtt ), 7(5), 13–17.

Guo, C., Zhou, L., & Lv, J. (2013). Effects of expandable graphite and modified ammonium polyphosphate on the flame-retardant and mechanical properties of wood flour-polypropylene composites. Polymers and Polymer Composites, 21(7), 449–456. https://doi.org/10.1002/app

Hamidi, M., Azadi, A., & Ra, P. (2008). Hydrogel nanoparticles in drug delivery, 60, 1638–1649. https://doi.org/10.1016/j.addr.2008.08.002

Hashemi, M., Ramezani, V., Seyedabadi, M., Ranjbar, A. M., & Jafari, H. (2017). Formulation and Optimization of Oral Mucoadhesive Patches of Myrtus Communis by Box Behnken Design. Tabriz University of Medical Sciences, 7(3), 441–450. https://doi.org/10.15171/apb.2017.053

Jung, H. W., Yoon, C. H., Park, K. M., Han, H. S., & Park, Y. K. (2009). Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF-kappaB pathway. Food and Chemical Toxicology, 47(6), 1190–1197. https://doi.org/10.1016/j.fct.2009.02.012

Khanghah, S. N., Babaee, N., Moghadamnia, A. A., & Kazemi, S. (2016). Impact of Nut Mug Bioadhesive on Minor Recurrent Aphthous Stomatitis, (2), 1438–1445.

Morales, J. O., & McConville, J. T. (2011). Manufacture and characterization of mucoadhesive buccal films. European Journal of Pharmaceutics and Biopharmaceutics, 77(2), 187–199. https://doi.org/10.1016/j.ejpb.2010.11.023

Mukherjee, D., & Bharath, S. (2013). Design and Characterization of Double Layered Mucoadhesive System Containing Bisphosphonate Derivative. ISRN Pharmaceutics, 2013, 1–10. https://doi.org/10.1155/2013/604690

Nair, P. K., & Dyasanoor, S. (2015). Clinical efficacy of allicin – A novel alternative therapeutic agent in the management of minor recurrent aphthous stomatitis, 231–236. https://doi.org/10.15713/ins.jcri.85

Omidian, H., Park, K., Kandalam, U., & Rocca, J. G. (2010). Swelling and Mechanical Properties of Modified HEMA-based Superporous Hydrogels. Journal of Bioactive and Compatible Polymers, 25(5), 483–497. https://doi.org/10.1177/0883911510375175

Özyazıcı, M., Fırlak, M., Tanrıverdı, S. T., Rençber, S., Karavana, Y., & Kahraman, M. V. (2015). Bioadhesive Gel and Hydrogel Systems for Buccal Delivery of Ketoprofen : Preparation and In vitro Evaluation Studies. American Journal of Drug Delivery and Therapeutics, 2(3), 078–091.

Patel, A., & Shah, D. (2016). Mucoadhesive Buccal Films Based on, 10(2), 2–4.

Patel, V. M., Prajapati, B. G., & Patel, M. M. (2007). Formulation, evaluation, and comparison of bilayered and multilayered mucoadhesive buccal devices of propranolol hydrochloride. AAPS PharmSciTech, 8(1), 22. https://doi.org/10.1208/pt0801022

Peppas, N. A., & Buri, P. A. (1985). Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. Journal of Controlled Release, 2(C), 257–275. https://doi.org/10.1016/0168-3659(85)90050-1

Press, D. (2012). A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles : in vivo / in vitro examinations, 5693–5704.

Ragwa M. Farid, M. M. W. (2017). Promote Recurrent Aphthous Ulcer Healing with Low Dose Prednisolone Bilayer Mucoadhesive Buccal Film. Current Drug Delivery, 1.

Ronald A. Sieel and Michael J. Rathbone. (2011). Overview of controlled release mechanism. In Fundamentals and Application of Controlled Release Drug Delivery. Springer.

Sizílio, R. H., Galvão, J. G., Trindade, G. G. G., Pina, L. T. S., Andrade, L. N., Gonsalves, J. K. M. C., … Nunes, R. S. (2018). Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis. Carbohydrate Polymers, 190(March), 339–345. https://doi.org/10.1016/j.carbpol.2018.02.079

Sudhakar, Y., Kuotsu, K., & Bandyopadhyay, A. K. (2006). Buccal bioadhesive drug delivery - A promising option for orally less efficient drugs. Journal of Controlled Release, 114(1), 15–40. https://doi.org/10.1016/j.jconrel.2006.04.012

Yaprak Karavana, S., Güneri, P., & Ertan, G. (2009). Benzydamine hydrochloride buccal bioadhesive gels designed for oral ulcers: Preparation, rheological, textural, mucoadhesive and release properties. Pharmaceutical Development and Technology, 14(6), 623–631. https://doi.org/10.3109/10837450902882351

Zand, N., Ataie-Fashtami, L., Djavid, G. E., Fateh, M., Alinaghizadeh, M. R., Fatemi, S. M., & Arbabi-Kalati, F. (2009). Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation. Lasers in Medical Science, 24(4), 515–520. https://doi.org/10.1007/s10103-008-0555-1

Zhang, C., Liu, Y., Li, W., Gao, P., Xiang, D., Ren, X., & Liu, D. (2018). Ac ce ed us cr, 7450. https://doi.org/10.1080/10837450.2018.1428814




DOI: https://doi.org/10.24198/jf.v16i2.17237

DOI (PDF): https://doi.org/10.24198/jf.v16i2.17237.g8472

Refbacks

  • Saat ini tidak ada refbacks.




Sitasi manajer:   

 

 

Jurnal ini diindeks dalam:

 

 

View My Stats 

ISSN: 1693-1424

e-ISSN: 2716-3075

 

Farmaka by Universitas Padjadjaran is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Copyright © 2013 Jurnal Farmaka - All Right Reserved