Email Artikel ini Tinjauan Pustaka Mengenai Karakteristik Radioisotop yang Digunakan pada Pembuatan Radiofarmaka
Abstrak
Radiofarmaka merupakan suatu obat yang biasa digunakan untuk diagnosis ataupun terapi. Perbedaan antara radiofarmaka dengan obat biasa adalah terkandungnya radioisotop. Radioisotop merupakan isotop yang bersifat tidak stabil sehingga akan memancarkan suatu energi radioaktif untuk mencapai bentuk yang stabilnya. Pancaran radioaktif yang ditimbulkan pada setiap jenis radioisotop yang digunakan pada radiofarmaka memiliki karakteristik yang berbeda. Perbedaan pada pancaran radioaktif mempengaruhi tujuan pengaplikasian radiofarmaka. Radioisotop yang memiliki sifat pemancar sinar gamma umum digunakan untuk diagnosis sedangkan yang memancarkan sinar beta umum digunakan untuk terapi. Karakteristik lain yang dilihat, antara lain sifat metal dan non metal radioisotop yang menyebabkan perbedaan metode pembuatan radiofarmaka.
Kata Kunci : Radiofarmaka, Radioisotop, sinar gamma, sinar beta.
Teks Lengkap:
PDFReferensi
Alzahrani, AS, S Bakheet, MA Mandil, A Al-hajjaj, A Almahfouz, and AA Haj. 2001. 123I isotope as a diagnostic agent in the follow-up of patient with differentiated thyroid cancer comparation with post 131I therapy whole body scannning. J Clin Endocrinol Metab 86:5194–5300.
ANSTO. 2006. Radioisotopes: their role in society today [online]. Available at http://www.ansto.gov.au/__data/assets/pdf_file/0018/3564/Radioisotopes.pdf (verified 13 June 2018)
Aslani, A, GM Snowdon, DL Bailey, GP Schembril, EA Bailey, and PJ Roach. 2014. Gallium-68 DODATE production with automated PET radiopharmaceutical synthesis system : a three year experience. Asia Ocean Journal of Nuclear Medicine & Biology 2:75–86.
Choenen Coenen, H. H., J Mertens, and B Maziere. 2006. Radioiodination Reactions for Radiopharmaceuticals, Compendium for Effective Synthesis Strategies. Springer Dordrecht, The Netherlands.
Chung, JK and GJ Cheon. 2014. Radioiodine therapy in differentiated thyroid cancer: The first targeted therapy in oncology. Endocrinol Metab 29:233–239.
Decristoforo, C, R Knopp, EV Guggenberg, M Rupprich, T Dreger, A Hess, I Virgolini, R Haubner. 2007. Nucl Med Commun 28:870–875.
Eshima, D and AJ Taylor. Technetium-99m (99mTc) Mercaptoacetyltriglycine: update on the new 99mTc renal tubular function agent. Semin Nucl Med 22:61–73.
Govindan, SV and Goldenberg, D.M. 2010. New antibody conjugates in cancer therapy. Sci. World Journal 10:2070–2089.
Guo, R, M Zhang, Y Xu, Y Ma, S Liang, S Shi, Y Miao, and B Li. 2014. Theranostic studies of human sodium iodide symporter imaging and therapy using 188Re : a human glioma study in mice. Plos One 9:1–8.
Jones, AG, MJ Abrams, A Davison, JW Brodack, AK Toothaker, SJ Adelstein, and AI Kassis. 1984. Biological studies of a new class of technetium complexes: the hexakis(alkylisonitrile)technetium(I) cations. Int J Nucl Med Biol 11:225–234.
Kartamiharja, AHS. 2012. Permasalahan Kedokteran Nuklir [online]. Available at http://pustaka.unpad.ac.id/wp-content/uploads/2015/06/PERMASALAHAN-PELAYANAN-KEDOKTERAN-NUKLIR-.pdf (verified 03 Jully 2018)
Levita, J and Mutakin. 2015. Radioiodinasi pada Pembuatan Radiofarmaka. Deepublish, Yogyakarta. 4p.
Masjhur, JS. 2000. Aplikasi teknik nuklir dalam kesehatan masa kini. Jurnal Sains dan Teknologi Nuklir Indonesia 1:29–42.
Nurlaila. 2002. Radiofarmaka Peptida untuk diagnosis dan terapi. Maj Kedokt Indonesia 57:265–273.
Papagiannopoulou, D. 2017. Technetium-99m radiochemistry for pharmaceutical applications. J Labelled Comp. Radiopharm 60:502–520.
Rosilawati, NE, I Nasution dan TW Murni. 2017. Penggunaan radiofarmaka untuk diagnosa dan terapi di Indonesia dan asas keamanan penggunaan obat. SOEPRA Jurnal Hukum Kesehatan 3:60–73.
Senduk, P, VR Danes, JF Rumampuk. 2015. Penggunaan radioisotop pada deteksi dini penyakit kanker. Jurnal e-biomedik 3:620–623.
Soenarjo, S. 2014. Mekanisme lokalisasi sediaan radiofarmaka pada organ target. Jurnal Radioisotop dan Radiofarmaka 17:15–26.
Suryanto, H, T Heryanto, SA Sarongalo, Rajiman and B Taringan. 2002. Pengembangan fasilitas iradiasi siklotron-BATAN untuk produksi Flour-18. Jurnal Radioisotop dan Radiofarmaka 5:53–66.
Uccelli, L, P Martini, M Pasquali, and A Boschi. 2017. Monoclonal antibodies radiolabeling with Rhenium-188 for radioimmunotherapy. Biomed Research International :1–7.
World Health Organization. 2008. Radiopharmaceutical [online]. Available at http://www.who.int/medicines/publications/pharmacopoeia/Radgenmono.pdf (verified 12 June 2018)
World Nuclear Assosiation. 2018. Radioisotopes in medicine [online]. Available at http://www.world-nuclear.org/information-library/non-power-nuclear-applications/radioisotopes-research/radioisotopes-in-medicine.aspx (verified 12 June 2018)
Wurdiyanto, G., Hermawan C. and Pujadi. 2009. Standardisasi F-18 Menggunakan Metode Spektrometri Gamma. Prosiding Seminar Nasional Sains dan Teknologi Nuklir PTNBR – BATAN : 227-231.
Zhang, Y, Y Zhang, L Yin, X Xia, F Hu, QY Liu, C Qin, X Lan. 2017. Synthesis and bioevaluation of Iodine-131 directly labeled cyclic RGD-PEGylated gold nanorods for tumor-targeted imaging. Contrast Media & Molecular Imaging 1:1-10.
Alzahrani, AS, S Bakheet, MA Mandil, A Al-hajjaj, A Almahfouz, and AA Haj. 2001. 123I isotope as a diagnostic agent in the follow-up of patient with differentiated thyroid cancer comparation with post 131I therapy whole body scannning. J Clin Endocrinol Metab 86:5194–5300.
ANSTO. 2006. Radioisotopes: their role in society today [online]. Available at http://www.ansto.gov.au/__data/assets/pdf_file/0018/3564/Radioisotopes.pdf (verified 13 June 2018)
Aslani, A, GM Snowdon, DL Bailey, GP Schembril, EA Bailey, and PJ Roach. 2014. Gallium-68 DODATE production with automated PET radiopharmaceutical synthesis system : a three year experience. Asia Ocean Journal of Nuclear Medicine & Biology 2:75–86.
Choenen Coenen, H. H., J Mertens, and B Maziere. 2006. Radioiodination Reactions for Radiopharmaceuticals, Compendium for Effective Synthesis Strategies. Springer Dordrecht, The Netherlands.
Chung, JK and GJ Cheon. 2014. Radioiodine therapy in differentiated thyroid cancer: The first targeted therapy in oncology. Endocrinol Metab 29:233–239.
Decristoforo, C, R Knopp, EV Guggenberg, M Rupprich, T Dreger, A Hess, I Virgolini, R Haubner. 2007. Nucl Med Commun 28:870–875.
Eshima, D and AJ Taylor. Technetium-99m (99mTc) Mercaptoacetyltriglycine: update on the new 99mTc renal tubular function agent. Semin Nucl Med 22:61–73.
Govindan, SV and Goldenberg, D.M. 2010. New antibody conjugates in cancer therapy. Sci. World Journal 10:2070–2089.
Guo, R, M Zhang, Y Xu, Y Ma, S Liang, S Shi, Y Miao, and B Li. 2014. Theranostic studies of human sodium iodide symporter imaging and therapy using 188Re : a human glioma study in mice. Plos One 9:1–8.
Jones, AG, MJ Abrams, A Davison, JW Brodack, AK Toothaker, SJ Adelstein, and AI Kassis. 1984. Biological studies of a new class of technetium complexes: the hexakis(alkylisonitrile)technetium(I) cations. Int J Nucl Med Biol 11:225–234.
Kartamiharja, AHS. 2012. Permasalahan Kedokteran Nuklir [online]. Available at http://pustaka.unpad.ac.id/wp-content/uploads/2015/06/PERMASALAHAN-PELAYANAN-KEDOKTERAN-NUKLIR-.pdf (verified 03 Jully 2018)
Levita, J and Mutakin. 2015. Radioiodinasi pada Pembuatan Radiofarmaka. Deepublish, Yogyakarta. 4p.
Masjhur, JS. 2000. Aplikasi teknik nuklir dalam kesehatan masa kini. Jurnal Sains dan Teknologi Nuklir Indonesia 1:29–42.
Nurlaila. 2002. Radiofarmaka Peptida untuk diagnosis dan terapi. Maj Kedokt Indonesia 57:265–273.
Papagiannopoulou, D. 2017. Technetium-99m radiochemistry for pharmaceutical applications. J Labelled Comp. Radiopharm 60:502–520.
Rosilawati, NE, I Nasution dan TW Murni. 2017. Penggunaan radiofarmaka untuk diagnosa dan terapi di Indonesia dan asas keamanan penggunaan obat. SOEPRA Jurnal Hukum Kesehatan 3:60–73.
Senduk, P, VR Danes, JF Rumampuk. 2015. Penggunaan radioisotop pada deteksi dini penyakit kanker. Jurnal e-biomedik 3:620–623.
Soenarjo, S. 2014. Mekanisme lokalisasi sediaan radiofarmaka pada organ target. Jurnal Radioisotop dan Radiofarmaka 17:15–26.
Suryanto, H, T Heryanto, SA Sarongalo, Rajiman and B Taringan. 2002. Pengembangan fasilitas iradiasi siklotron-BATAN untuk produksi Flour-18. Jurnal Radioisotop dan Radiofarmaka 5:53–66.
Uccelli, L, P Martini, M Pasquali, and A Boschi. 2017. Monoclonal antibodies radiolabeling with Rhenium-188 for radioimmunotherapy. Biomed Research International :1–7.
World Health Organization. 2008. Radiopharmaceutical [online]. Available at http://www.who.int/medicines/publications/pharmacopoeia/Radgenmono.pdf (verified 12 June 2018)
World Nuclear Assosiation. 2018. Radioisotopes in medicine [online]. Available at http://www.world-nuclear.org/information-library/non-power-nuclear-applications/radioisotopes-research/radioisotopes-in-medicine.aspx (verified 12 June 2018)
Wurdiyanto, G., Hermawan C. and Pujadi. 2009. Standardisasi F-18 Menggunakan Metode Spektrometri Gamma. Prosiding Seminar Nasional Sains dan Teknologi Nuklir PTNBR – BATAN : 227-231.
Zhang, Y, Y Zhang, L Yin, X Xia, F Hu, QY Liu, C Qin, X Lan. 2017. Synthesis and bioevaluation of Iodine-131 directly labeled cyclic RGD-PEGylated gold nanorods for tumor-targeted imaging. Contrast Media & Molecular Imaging 1:1-10.
Alzahrani, AS, S Bakheet, MA Mandil, A Al-hajjaj, A Almahfouz, and AA Haj. 2001. 123I isotope as a diagnostic agent in the follow-up of patient with differentiated thyroid cancer comparation with post 131I therapy whole body scannning. J Clin Endocrinol Metab 86:5194–5300.
ANSTO. 2006. Radioisotopes: their role in society today [online]. Available at http://www.ansto.gov.au/__data/assets/pdf_file/0018/3564/Radioisotopes.pdf (verified 13 June 2018)
Aslani, A, GM Snowdon, DL Bailey, GP Schembril, EA Bailey, and PJ Roach. 2014. Gallium-68 DODATE production with automated PET radiopharmaceutical synthesis system : a three year experience. Asia Ocean Journal of Nuclear Medicine & Biology 2:75–86.
Choenen Coenen, H. H., J Mertens, and B Maziere. 2006. Radioiodination Reactions for Radiopharmaceuticals, Compendium for Effective Synthesis Strategies. Springer Dordrecht, The Netherlands.
Chung, JK and GJ Cheon. 2014. Radioiodine therapy in differentiated thyroid cancer: The first targeted therapy in oncology. Endocrinol Metab 29:233–239.
Decristoforo, C, R Knopp, EV Guggenberg, M Rupprich, T Dreger, A Hess, I Virgolini, R Haubner. 2007. Nucl Med Commun 28:870–875.
Eshima, D and AJ Taylor. Technetium-99m (99mTc) Mercaptoacetyltriglycine: update on the new 99mTc renal tubular function agent. Semin Nucl Med 22:61–73.
Govindan, SV and Goldenberg, D.M. 2010. New antibody conjugates in cancer therapy. Sci. World Journal 10:2070–2089.
Guo, R, M Zhang, Y Xu, Y Ma, S Liang, S Shi, Y Miao, and B Li. 2014. Theranostic studies of human sodium iodide symporter imaging and therapy using 188Re : a human glioma study in mice. Plos One 9:1–8.
Jones, AG, MJ Abrams, A Davison, JW Brodack, AK Toothaker, SJ Adelstein, and AI Kassis. 1984. Biological studies of a new class of technetium complexes: the hexakis(alkylisonitrile)technetium(I) cations. Int J Nucl Med Biol 11:225–234.
Kartamiharja, AHS. 2012. Permasalahan Kedokteran Nuklir [online]. Available at http://pustaka.unpad.ac.id/wp-content/uploads/2015/06/PERMASALAHAN-PELAYANAN-KEDOKTERAN-NUKLIR-.pdf (verified 03 Jully 2018)
Levita, J and Mutakin. 2015. Radioiodinasi pada Pembuatan Radiofarmaka. Deepublish, Yogyakarta. 4p.
Masjhur, JS. 2000. Aplikasi teknik nuklir dalam kesehatan masa kini. Jurnal Sains dan Teknologi Nuklir Indonesia 1:29–42.
Nurlaila. 2002. Radiofarmaka Peptida untuk diagnosis dan terapi. Maj Kedokt Indonesia 57:265–273.
Papagiannopoulou, D. 2017. Technetium-99m radiochemistry for pharmaceutical applications. J Labelled Comp. Radiopharm 60:502–520.
Rosilawati, NE, I Nasution dan TW Murni. 2017. Penggunaan radiofarmaka untuk diagnosa dan terapi di Indonesia dan asas keamanan penggunaan obat. SOEPRA Jurnal Hukum Kesehatan 3:60–73.
Senduk, P, VR Danes, JF Rumampuk. 2015. Penggunaan radioisotop pada deteksi dini penyakit kanker. Jurnal e-biomedik 3:620–623.
Soenarjo, S. 2014. Mekanisme lokalisasi sediaan radiofarmaka pada organ target. Jurnal Radioisotop dan Radiofarmaka 17:15–26.
Suryanto, H, T Heryanto, SA Sarongalo, Rajiman and B Taringan. 2002. Pengembangan fasilitas iradiasi siklotron-BATAN untuk produksi Flour-18. Jurnal Radioisotop dan Radiofarmaka 5:53–66.
Uccelli, L, P Martini, M Pasquali, and A Boschi. 2017. Monoclonal antibodies radiolabeling with Rhenium-188 for radioimmunotherapy. Biomed Research International :1–7.
World Health Organization. 2008. Radiopharmaceutical [online]. Available at http://www.who.int/medicines/publications/pharmacopoeia/Radgenmono.pdf (verified 12 June 2018)
World Nuclear Assosiation. 2018. Radioisotopes in medicine [online]. Available at http://www.world-nuclear.org/information-library/non-power-nuclear-applications/radioisotopes-research/radioisotopes-in-medicine.aspx (verified 12 June 2018)
Wurdiyanto, G., Hermawan C. and Pujadi. 2009. Standardisasi F-18 Menggunakan Metode Spektrometri Gamma. Prosiding Seminar Nasional Sains dan Teknologi Nuklir PTNBR – BATAN : 227-231.
Zhang, Y, Y Zhang, L Yin, X Xia, F Hu, QY Liu, C Qin, X Lan. 2017. Synthesis and bioevaluation of Iodine-131 directly labeled cyclic RGD-PEGylated gold nanorods for tumor-targeted imaging. Contrast Media & Molecular Imaging 1:1-10.
DOI: https://doi.org/10.24198/jf.v16i1.17452
DOI (PDF): https://doi.org/10.24198/jf.v16i1.17452.g8637
Refbacks
Sitasi manajer:
Jurnal ini diindeks dalam:
Farmaka by Universitas Padjadjaran is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Copyright © 2013 Jurnal Farmaka - All Right Reserved