Email Artikel ini FORMULASI NANOEMULSI UNTUK MENINGKATKAN KELARUTAN OBAT LIPOFILIK : ARTICLE REVIEW
Abstrak
Pengembangan formulasi obat dan system penghantaran obat sangat pesat. Masalah yang dihadapi saat ini dalam formulasi obat adalah kelarutan zat aktif yang kurang. Hal ini terjadi pada obat dengan BCS kelas II dimana obat memiliki permeabilitas tinggi namun kelarutannya rendah sehingga berdampak pada rendahnya bioavailabilitas. Nanoemulsi merupakan salah satu formulasi yang berperan penting dalam memperbaiki kelarutan obat lipofilik. Tujuan penulisan ulasan artikel ini adalah untuk menguraikan konsep dan teknik nanoemulsi dalam upaya peningkatan bioavailabilitas obat yang kelarutannya rendah dalam air. Metode yang digunakan adalah dengan studi literatur tentang nanoemulsi dari database, pubmed dan medline dengan memasukkan kata kunci nanoemulsi dan SNEDDS. Terdapat banyak sediaan obat oral maupun trandermal yang telah dibuat dalam bentuk nanoemulsi. Sediaan tersebut harus melewati proses karakterisasi dan evaluasi terlebih dahulu sebelum dirilis ke pasaran.
Kata Kunci: nanoemulsi, SNEDDS (Self-nanoemulsifying Drug Delivery System), studi kelarutan, pelepasan obat, stabilitas.
ABSTRACT
The development of drug formulations and drug delivery systems is very rapid. The current problem faced in drug formulation is low solubility of active pharmaceutical ingridients. This problem occurs in BCS class II drug where the drug has a high permeability but low solubility. Nanoemulsis is dosage form Thar plays an important role in improving lipophilic drug solubility. The purpose of this article review is to describe the concept and techniques of nanoemulsion in an effort to increase the bioavailability of drugs Thar has low solubility in water. The method used is a literature study of nanoemulsion from database, pubmed and medline by entering nanoemulsion and SNEDDS keywords. There are many oral or trandermal drug preparations that have been made in the form of nanoemulsion. The preparation must pass through the characterization and evaluation process before being marketed.
Keywords: nanoemulsion, SNEDDS (Self-nanoemulsifying Drug Delivery System), solubility studies, drug release, and stability
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DOI: https://doi.org/10.24198/jf.v16i1.17502
DOI (PDF): https://doi.org/10.24198/jf.v16i1.17502.g8660
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