Article review : FORMULASI DAN EVALUASI MICRONEEDLE DENGAN BERBAGAI MACAM POLIMER SEBAGAI ZAT PEMBAWA OBAT

ALODIA ROSALINA, IMAM ADI WICAKSONO

Abstrak


ABSTRAK

Baru-baru ini, microneedle untuk pengiriman obat transdermaltelah dikembangkan sebagai metode praktis untuk mengirim agen kimia dan biologi yang efektif mengatasi stratum korneum sebagai pengalang utama kulit dan memberikan obat secara efektif ke dalam kulit. Article review ini dibuat untuk mengetahui hasil dari percobaan-percobaan yang telah dilakukan dalam pembuatan microneedle dengan polimer yang diharapkan dapat berguna untuk memberikan informasi mengenai microneedle dengan polimer. Berdasarkan hasil dari pencarian literatur, microneedle polimer memberikan keuntungan kemudahan fabrikasi, efektivitas biaya, serta pelepasan obat yang dapat dikontrol menggunakansifat kelarutan air dan degradasi polimer.Hasil percobaan pada berbagai literatur menunjukkan bahwa microneedle polimer merupakan salah satu terobosan baru dalam bidang teknologi farmasi yang mampu memberikan efektifitas terapetik yang baik pada berbagai macam obat dan berbagai biomolekul seperti vaksin dan hormon.

Kata Kunci : Kulit, Microneedle, Polimer, Transdermal

ABSTRACT

Recently, a microneedle system has been developed to deliver chemical and biological agents through the stratum corneum,which is the main barrier to drug delivery. Based on the results of literature searches, polymer microneedles offerthe benefits of ease of fabrication and cost-effectiveness, as well as controlled drug release usingthe water solubility and degradation properties of polymer. This article review was made to determine the results of experiments that have been made in the manufacture of microneedles with polymers which are expected to be useful for providing information on microneedles with polymers.Experimental results in various literatures show that microneedle polymer is one of the new breakthroughs in the field of pharmaceutical technology that is capable of providing good therapeutic efficacy on various drugs and various biomolecules such as vaccines and hormones.

Keywords :Microneedle, Polymer, Skin, Transdermal

Teks Lengkap:

PDF

Referensi


Boehm, RD, PR Miller, R Singh, A Shah, S Stafslien, J Daniels, RJ Narayan. 2012. Indirect Rapid Prototyping of Antibacterial Acid Anhydride Copolymer Microneedles. Biofabrication 4.

Budamakuntla L., et al. 2013. A Randomised, Open-label, Comparative Study of Tranexamic Acid Microinjections and Tranexamic Acid With Microneedling In Patients With Melasma. Journal Cutan Aesthet Surg 6(3):139–143.

Chandrashekar, BS, V Yepuri, V Mysore. 2014. Alopecia Areata – Successful Outcome with Microneedling and Triamcinolone Acetonide. Journal Cutan Aesthet Surg 7(1):63–64.

Donnelly, RF., et.al. 2010. Microneedle-mediated Intradermal Nanoparticle Delivery: Potential for Enhanced Local Administration of Hydrophobic Pre-formed Photosensitisers. Photodiagnosis Photodyn Ther 7 : 222 – 231.

Donnelly, RF., et.al. 2009. Processing Difficulties and Instability of Carbohydrate Microneedle Arrays.Drug Dev Ind Pharm 35: 1242–1254.

Dhurat R., et al. 2013. A Randomized Evaluator Blinded Study of Effect of Microneedling In Androgenetic Alopecia: APilot Study. International Journal Trichol 5(1):6–11.

Fukushima, K., et.al. 2011. Two-layered Dissolving Microneedles for Percutaneous Delivery of Peptide/Protein Drugs In Rats. Pharmacy Res 28: 7 – 21.

Garland, MJ, E Caffarel-Salvador, K Migalska, AD Woolfson, RF Donnelly. 2012a. Dissolving Polymeric Microneedle Arrays for Electrically Assisted Transdermal Drug Delivery. Journal Control Release 159: 52–59.

Garland, MJ, et.al. 2012b. Influence of Skin Model On In Vitro Performance of Drug-loaded Soluble Microneedle Arrays. International Journal Pharmacy 434: 80–89.

Ito, Y, A Murakami, T Maeda, N Sugioka, K Takada. 2008. Evaluation ofSelf-Dissolving Needles Containing Low Molecular Weight Heparin (LMWH) In Rats. International Journal Pharmacy, 349: 124–129.

Ito, Y, H Murano, N Hamasaki, K Fukushima, K Takada. 2011. Incidence of Low Bioavailability of Leuprolide Acetate After Percutaneous Administration to Rats by Dissolving Microneedles. International Journal Pharmacy 407: 126–131.

Kalluri, H, and AK Banga. 2011. Formation and Closure of Microchannels In Skin Following Microporation. Pharm Res 28: 82–94.

Kearney, M-C, E Caffarel-Salvandor, SJ Fallows, HO McCarthy, RF Donnelly. 2016. Microneedle-mediated delivery of donepezil: Potential for Improved Treatment Options in Alzheimer’s Disease. European Journal of Pharmaceutics and Biopharmaceutics 103 : 43 – 50.

Kim, M, B Jung, JH Park. 2012. Hydrogel Swelling as a Trigger to Release Biodegradable Polymer Microneedles In Skin. Biomaterials 33: 668–678.

Kim, SE, JH Lee, HB Kwon, BJ Ahn, AY Lee. 2011. Greater Collagen Deposition With The Microneedle Therapy System Than with Intense Pulsed Light. Dermatol Surg 37: 336–341.

Kim, Y, F Quan, RW Compans, S Kang, MR Prausnitz. 2010. Formulation and Coating of Microneedles with Inactivated Influenza Virus To Improve Vaccine Stability and Immunogenicity. Journal Control Release 142(2) : 187 – 195.

Kolli, CS, and AK Banga. 2008. Characterization of Solid Maltose Microneedles and Their Use for Transdermal Delivery. Pharm Res 25: 104–113.

Kuo, HC, Y Lin, YK Shen, SC Kang. 2011. Invasive PLA Microneedle Fabrication Applied To Drug Delivery Dystem. International Conference On Mechanical Automation and Control Engineering, ISSN : 7437–7440.

Larraneta, E, EM Rebecca, A Lutton, D Woolfson, RF Donnelly. 2016. Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. Materials Science and Engineering 104 : 1 – 32.

Lee, J. W., Park, J. H., Prausnitz, M. R. 2008. Dissolving Microneedles for Transdermal Drug Delivery. Biomaterials 29: 2113–2124.

Lee, JW, SO Choi, EL Felner, MR Prausnitz. 2011. Dissolving Microneedle Patch for Transdermal Delivery of Human Growth Hormone. Small 7: 531–539.

Ling, MH., and MC Chen. 2013. Dissolving Polymer Microneedle Patches for Rapid and Efficient Transdermal Delivery of Insulin To Diabetic Rats. Acta Biomater 9 : 8952 – 8961.

Maaden, VDK, W Jiskoot, J Bouwstra. 2012. Microneedle Technologies for Transdermal Drug and Vaccine Delivery. Journal Control Release 161: 645 – 655.

Machekposthi, SA, M Soltani, P Najafizadeh, SA Ebrahimi, P Chen. 2017. Biocompatible Polymer Microneedle For Topical/Dermal Delivery of Tranexamic Acid. Journal of Controlled Release 261 : 87 – 92.

McCrudden, MT., et.al. 2014. Design and Physicochemical Characterisation of Novel Dissolving Polymeric Microneedle Arrays for Transdermal Delivery of High Dose,Low Molecular Weight Drugs. Journal of Controlled Release 180 : 71 – 80.

Mogusala, NR, VR Devadasu, and RK Venisetty. 2015. Fabrication of Microneedle Molds and Polymer Based Biodegradable Microneedle Patches : A Novel Method. American Journal of Drug Delivery and Therapeutics, ISSN 2349-7211.

Park, JH, and MR Prausnitz. 2010. Analysis of Mechanical Failure of PolymerMicroneedles by Axial Force. Journal Korean Phys Soc 56: 1223–1227.

Qiu, YQ., et.al. 2016. Systemic Delivery of Artemether by Dissolving Microneedles. International Journal Pharmacy 508: 1 – 9.

Raphael, AP, TW Prow, ML Crichton, X Chen, GJ Fernando, MA Kendall. 2010. Targeted, Needle-free Vaccinations In Skin Using Multilayered, Densely-packed Dissolving Microprojection Arrays. Small 6 : 1785–1793.

Serrano, G., et.al. 2015. Microneedling Dilates The Follicular Infundibulum and Increases Transfollicular Absorption of Liposomal Sepia Melanin. Clinical, Cosmetic and Investigational Dermatology 8 : 313 – 318.

So, J, H Park, SS Lee, D Kim, S Shin, and C Cho. 2009. Effect of Microneedle On The Pharmacokinetics of Ketoprofen from Its Transdermal Formulations. Drug Delivery 16(1) : 52 – 56.

Sullivan, SP., et.al. 2010. Dissolving Polymer Microneedle Patches for InfluenzaVaccination. National Med 16: 915–920.

Sullivan, SP, N Murthy, MR Prausnitz. 2008. Minimally Invasive ProteinDelivery with Rapidly Dissolving Polymer Microneedles. Adv Mater 20 : 933.

Stahl, J, M Wohlert, M Kietmann. 2012. Microneedle Pretreatment Enhances The Percutaneous Permeation of Hydrophilic Compounds with High Melting Points. BMC Pharmacology and Toxicology 13 (5) : 1 – 7.

Wang, MW, and JH Jeng. 2009. Optimal Molding Parameter Design of PLA Micro Lancet Needles Using the Taguchi Method. Polym-Plast Technol 48 : 730–735.

Yang, G, M He, S Zhang, M Wu, and Y Gao. 2017. An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron [Online]. Tersedia di http://www.tandfonline.com/loi/iddi20. [Diakses pada tanggal 18 Juni 2018].

Zhang, Y, G Jiang, W Y, D Liu, B Xu. 2018. Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats. Material Science & Engineering C : Materials for Biological Application [Online]. Tersedia di https://www.ncbi.nlm.nih.gov/pubmed/29407146. [Diakses pada tanggal 3 Juni 2018].




DOI: https://doi.org/10.24198/jf.v16i3.17779

DOI (PDF): https://doi.org/10.24198/jf.v16i3.17779.g8994

Refbacks

  • Saat ini tidak ada refbacks.




Sitasi manajer:   

 

 

Jurnal ini diindeks dalam:

 

 

View My Stats 

ISSN: 1693-1424

e-ISSN: 2716-3075

 

Farmaka by Universitas Padjadjaran is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Copyright © 2013 Jurnal Farmaka - All Right Reserved