REVIEW ARTIKEL : PERBANDINGAN PENGUJIAN ENDOTOKSIN UNTUK SEDIAAN FARMASI

NUR DIANA HADAD, ADE ZUHROTUN

Abstrak


Endotoksin adalah molekul hidrofobik kecil yang merupakan bagian dari kompleks lipopolisakarida (LPS) yang membentuk sebagian besar membran luar bakteri gram negatif. Ketika molekul LPS bersirkulasi dalam tubuh manusia, berbagai sitokin inflamasi yang diekspresikan secara berlebihan oleh aktivasi sistem imun bawaan dan menyebabkan inflamasi sistemik. Artikel ini mengulas mengenai perbandingan pengujian endotoksin yang banyak digunakan untuk sediaan farmasi. Metode yang digunakan pada artikel review ini adalah melalui pencarian data ilmiah yang dilakukan secara online pada database PubMed, Science Direct, Research Gate dan Google Scholar dengan kata kunci yakni “Bacterial Endotoxin Test”, “Endotoxin”, “Gel-clot”, “Turbidimetric” dan “Chromogenic”. Dari hasil penelusuran dan pengumpulan data tersebut diketahui bahwa metode pengujian endotoksin yang banyak digunakan yaitu gel-clot, Turbidimetri, dan kromogenik, setiap metode tersebut memilki kekurangan dan kelebihannya masing-masing.

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DOI: https://doi.org/10.24198/farmaka.v19i4.22076

DOI (PDF): https://doi.org/10.24198/farmaka.v19i4.22076.g16840

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