Kajian Metode Isolasi Jantung Hewan dalam Pengujian Aktivitas Kardiotonik suatu Senyawa

Nurike Susendi, Sri Adi Sumiwi, Aliya Nur Hasanah

Abstrak


Agen kardiotonik yang digunakan dalam terapi utama ialah glikosida jantung dan katekolamin tetapi kedua obat tersebut memiliki efek samping yang bahaya. Maka perlu dilakukan pengembangan obat baru yang memiliki efektivitas obat yang baik dan efek samping yang kecil. Dalam metode pengujian kardiotonik seringkali menggunakan metode Isolated Heart Perfussion dengan hewan percobaan yang berbeda. Artikel review ini akan membahas terkait pengujian aktivitas kardiotonik dan hewan uji yang sering digunakan. Metode isolasi jantung yang saat ini digunakan adalah Langendroff method, dan modifikasinya dalam hal larutan serta kondisi pengujian. Dalam metode Langendroff berbagai kondisi harus dijaga diantaranya pemberian oksigen, nutrisi, suhu, serta tekanan perfusi Hewan uji yang efektif dalam pengujian aktivitas kardiotonik ialah katak karena model jantungnya dapat menjelaskan banyak prinsip penting fungsi kardiovaskular. Kata Kunci : Kardiotonik, Isolasi Perfusi Jantung, Langendroff method

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DOI: https://doi.org/10.24198/jf.v17i3.22093

DOI (PDF): https://doi.org/10.24198/jf.v17i3.22093.g12490

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