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Review: Konsep BDDCS (Biopharmaceutical Drug Disposition Classification) sebagai Landasan Pengembangan Produk Obat
Abstrak
Tantangan dalam proses penemuan dan pengembangan obat salah satunya adalah memprediksi secara klinis interaksi obat. Sehingga para ilmuan baru-baru ini banyak menggunakan Sistem Klasifikasi Disposisi Obat Biofarmasi atau dikenal dengan BDDCS untuk membantu menentukan hal tersebut. BDDCS mampu memprediksi metabolisme enzim dan efek transporter pada disposisi obat sehingga dapat menentukan ketersediaan hayati obat di dalam tubuh. BDDCS juga berguna dalam memprediksi: interaksi obat-obat; toksisitas; efek farmakogenomik dan substrat endogen; efek makanan; efek ke sistem saraf pusat; rute eliminasi obat; dan resistensi obat yang dimediasi oleh transporter. Sehingga BDDCS bisa menjadi alat prediksi yang kuat setiap kali transporter obat terlibat dalam proses fisiologis dan dapat dijadikan landasan pada tahap awal proses penemuan dan pengembangan obat.
Kata Kunci : Biopharmaceutics Drug Disposition Classification System (BDDCS), efek transporter pengembangan obat, tingkat metabolisme
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