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Interaksi Antara Zat Aktif dan Eksipien dalam Sediaan Farmasi
Abstrak
Perkembangan formula pada sediaan farmasi semakin pesat terbukti dengan adanya bentuk sediaan baru serta campuran eksipien pendukung yang rumit. Pengembangan suatu formula tidaklah mudah karena perlu bertahun-tahun agar mendapatkan hasil yang optimal. Salah satu permasalahan dalam pengembangan formula adalah interaksi yang terjadi pada formula tersebut, terutama pada zat aktif dengan eksipien maupun degradannya. Interaksi yang terjadi dapat berupa interaksi fisika seperti pembentukan kompleks, adsorpsi dan dispersi solida ; sedangkan untuk interaksi kimia seperti reaksi Maillard, dan transesterifikasi. Pada studi pustaka ini akan dibahas bagaimana interaksi tersebut terjadi antara zat aktif-eksipien pada sediaan farmasi.
Kata Kunci : Degradan, Interaksi Fisika, Interaksi Kimia.
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