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Sistem Penghantaran Sediaan Optalmik dengan In Situ Gel
Abstrak
Sediaan gel in situ optalmik merupakan sediaan yang diberikan dalam bentuk cair kemudian bergeser ke dalam fase gel karena adanya pemicu tertentu seperti pH, suhu, dan keberadaan ion. Sediaan optalmik konvensional seperti larutan, salep, dan suspensi memiliki beberapa kekurangannya seperti waktu kontak yang singkat dengan kornea dan penglihatan kabur ketika pemakaian. Pembuatan sediaan gel in situ bertujuan untuk mengatasi kekurangan sediaan optalmik konvensional karena lebih nyaman digunakan dan waktu kontak dengan kornea lebih lama. Beberapa evaluasi terhadap gel in situ optalmik dilakukan untuk memastikan bahwa sediaan yang dibuat telah memenuhi standar dan aman digunakan.
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