Stabilitas Hidrogel dalam Penghantaran Obat

M. Ramadhan Saputro, Yoga Windhu Wardhana, Nasrul Wathoni

Abstrak

Produk obat yang diproduksi harus dilakukan pengujian stabilitas guna untuk mengetahui umur simpan dan jalur degradasi suatu obat. Produk obat seperti hidrogel sangat rentan terjadi penurunan mutu kualitas. Sehingga pengujian stabilitas penting dilakukan terutama terkait dalam proses pengajuan izin edar suatu produk. Oleh karena itu, tujuan dari review artikel untuk mengetahui parameter pengujian stabilitas hidrogel, jalur degradasi dan bahan yang dapat meningkatkan stabilitas sediaan hidrogel. Parameter pengujian yang dilakukan beberapa literatur seperti fisika (organoleptis, titik leleh), kimia (kandungan obat, pH) dan mikrobiologi. Sediaan hidrogel umumnya terdegradasi melalui jalur kimiawi seperti oksidasi dan hidrolisis, oleh karena itu, perlu menanggulanggi dari kekurangan tersebut, yang diantaranya yaitu dengan penambahan polimer alami maupun sintesis serta modifikasi sediaan hidrogel guna meningkatkan stabilitas sebagai sistem penghantaran obat.

Kata Kunci

Degradasi, Hidrogel, Oksidasi, Stabilitas

Teks Lengkap:

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Referensi

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DOI: https://doi.org/10.24198/mfarmasetika.v6i5.35705

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