Review: Formulasi dan Evaluasi Tablet Pelepasan Tertunda dan Pelepasan Terkontrol

Ira Dwi Fatma, Yuni Kartika, Raden Roro Maryana Ulfah, Muhammad Dodit Rinaldi, Reza Pratama, Muhamad Reza Pahlevi

Abstrak

Tablet merupakan suatu bentuk sediaan padat yang mengandung zat aktif dan zat tambahan yang meliputi bahan pengikat, pengisi, penghancur, dan pelicin. Modified Release ini terbagi menjadi dua sistem pelepasan obat yaitu pelepasan tertunda (Delayed Release) dan pelepasan terkontrol (Controlled Release). Tablet lepas terkendali (Controlled Release tablet) adalah pelepasan senyawa yang dapat disesuaikan pada tingkat yang efektif sebagai respon terhadap waktu dan rangsangan. Tablet lepas tertunda (Delayed release tablet) adalah obat yang dilepaskan pada waktu yang lebih lambat setelah pemberian. Metode yang digunakan dalam review ini adalah dengan melakukan penelusuran studi pustaka secara elektronik dengan cara mengakses situs pencarian jurnal internasional dan nasional yang berkaitan  dengan  kata  kunci “Modified Release, Delayed Release, Controlled Release”. Untuk menjamin suatu mutu sediaan obat perlu dilakukan evaluasi. Evaluasi tablet meliputi uji keseragaman bobot, kerapuhan tablet, kekerasan tablet dan disolusi tablet.

Kata Kunci

Controlled Release, Delayed Release, Modified Release

Teks Lengkap:

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Referensi

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DOI: https://doi.org/10.24198/mfarmasetika.v9i5.56260

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