Nanoparticle Drug Delivery System

Auliya Afinasari, Eri Amalia

Abstract

Drug Delivery System is a method of drug formulation, which aims to deliver the active substance to achieve a therapeutic effect in the body. Along with the development of science in the field of drug manufacturing technology, drug delivery systems have evolved from conventional to targeted delivery systems and even nanorobots, gene therapy, biological products, and long-term delivery systems.

Among the drug delivery systems that have been developed, nanotechnology has been applied as a targeted delivery system such as in cancer treatment. This review is focused on nanotechnology especially in nanoparticle dosage forms, including liposomes, dendrimers, niosomes, micelles, solid-lipid nanoparticles, nanospheres, nanocapsules, and gold nanoparticles. The data were collected from 41 primary published journals and 20 supporting literatures. The basic principles, strategies, and carrier systems used in the manufacture of each preparation will be presented in this article, including prospects in the future for SOPs.

Full Text:

PDF HTML

References

Alhara Yuwanda SSMS, Dewi Rahmawati SFMF, apt. Rizky Farmasita B SFMF, Indonesia MS. Sistem Penghantaran Obat dan Pentargetan Sediaan Nanopartikel dan Penghantarannya. Media Sains Indonesia; 2021.

Wang J, Ni Q, Wang Y, Zhang Y, He H, Gao D, et al. Nanoscale drug delivery systems for controllable drug behaviors by multi-stage barrier penetration. J Control Release. 2021;331:282–95.

Tewabe A, Abate A, Tamrie M, Seyfu A, Abdela Siraj E. Targeted Drug Delivery - From Magic Bullet to Nanomedicine: Principles, Challenges, and Future Perspectives. J Multidiscip Healthc. 2021;14:1711–24.

Mu Y, Gong L, Peng T, Yao J, Lin Z. Advances in pH-responsive drug delivery systems. OpenNano. 2021;5:100031.

Sukmawati A, Da’i M, Zulinar F, Hanik A. Profil Pelepasan Antikanker kombinasi Doksorubisin dan Analog Kurkumin dari Nanopartikel Kitosan. URECOL. 2017;139–44.

Saiyad M, Shah N. Nanopolymers in drug delivery system. Mater Today Proc. 2022;

Park H, Otte A, Park K. Evolution of drug delivery systems: From 1950 to 2020 and beyond. J Control Release. 2022 Feb 1;342:53–65.

Yun YH, Lee BK, Park K. Controlled Drug Delivery: Historical perspective for the next generation. J Control Release. 2015/10/09. 2015 Dec 10;219:2–7.

Kim E, Erdos G, Huang S, Kenniston TW, Balmert SC, Carey CD, et al. Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development. EBioMedicine. 2020;55:102743.

Hryniewicz BM, Volpe J, Bach-Toledo L, Kurpel KC, Deller AE, Soares AL, et al. Development of polypyrrole (nano)structures decorated with gold nanoparticles toward immunosensing for COVID-19 serological diagnosis. Mater Today Chem. 2022;24:100817.

Wang C, Piao J, Li Y, Tian X, Dong Y, Liu D. Construction of Liposomes Mimicking Cell Membrane Structure through Frame-Guided Assembly. Angew Chemie Int Ed. 2020 Aug 24;59(35):15176–80.

Alam MI, Paget T, Elkordy AA. Formulation and advantages of furazolidone in liposomal drug delivery systems. Eur J Pharm Sci. 2016;84:139–45.

Zhang H. Thin-Film Hydration Followed by Extrusion Method for Liposome Preparation. Methods Mol Biol. 2017;1522:17–22.

Ghanbarzadeh S, Valizadeh H, Zakeri-Milani P. Application of response surface methodology in development of sirolimus liposomes prepared by thin film hydration technique. Bioimpacts. 2013/04/30. 2013;3(2):75–81.

FDA. No Title [Internet]. [cited 2022 Jun 17]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/050718s029lbl.pdf

Anselmo AC, Mitragotri S. Nanoparticles in the clinic: An update. Bioeng Transl Med. 2019 Sep 5;4(3):e10143–e10143.

Rahmi D. Review Dendrimer: Definisi, Sintesis, Aplikasi Dan Prospektif. J Kim dan Kemasan. 2013;35(2):137–44.

Maingi V, Kumar MVS, Maiti PK. PAMAM Dendrimer–Drug Interactions: Effect of pH on the Binding and Release Pattern. J Phys Chem B. 2012 Apr 12;116(14):4370–6.

Das I, Borah JH, Sarma D, Hazarika S. Synthesis of PAMAM dendrimer and its derivative PAMOL: Determination of thermophysical properties by DFT. J Macromol Sci Part A. 2018 Jul 3;55(7):544–51.

Bondareva J, Rozhkov V, Kachala V V, Fetyukhin V, Lukin O. An optimized divergent synthesis of sulfonimide-based dendrimers achieving the fifth generation. Synth Commun. 2019;49(24):3536–45.

Gillani SS, Munawar MA, Khan KM, Chaudhary JA. Synthesis, characterization and applications of poly-aliphatic amine dendrimers and dendrons. J Iran Chem Soc. 2020;17(11):2717–36.

Kelly BD, McLeod V, Walker R, Schreuders J, Jackson S, Giannis M, et al. Abstract 1716: Anticancer activity of the taxane nanoparticles, DEP® docetaxel and DEP® cabazitaxel. Cancer Res. 2020 Aug 15;80(16_Supplement):1716.

Madaan K, Kumar S, Poonia N, Lather V, Pandita D. Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues. J Pharm Bioallied Sci. 2014 Jul;6(3):139–50.

Marianecci C, Di Marzio L, Rinaldi F, Celia C, Paolino D, Alhaique F, et al. Niosomes from 80s to present: The state of the art. Adv Colloid Interface Sci. 2014;205:187–206.

Asaithambi K, Muthukumar J, Chandrasekaran R, Ekambaram N, Roopan M. Synthesis and characterization of turmeric oil loaded non-ionic surfactant vesicles (niosomes) and its enhanced larvicidal activity against mosquito vectors. Biocatal Agric Biotechnol. 2020;29:101737.

Ravalika V, krishna sailaja A. Formulation and Evaluation of Etoricoxib Niosomes by Thin Film Hydration Technique and Ether Injection Method. Nano Biomed Eng. 2017 Jan 1;9.

Javani R, Hashemi FS, Ghanbarzadeh B, Hamishehkar H. Quercetin-loaded niosomal nanoparticles prepared by the thin-layer hydration method: Formulation development, colloidal stability, and structural properties. LWT. 2021;141:110865.

Kaur D, Kumar S. Niosomes: present scenario and future aspects. J drug Deliv Ther. 2018;8(5):35–43.

Ahmed A, Ghorab M, Gad S, Qushawy M. Design, formulation, and evaluation of piroxicam niosomal gel. Int J PharmTech Res. 2014 Jan 1;6:185–95.

Althomali NM, Alshammari RS, Al-atawi TS, Aljohani AA. Impact of Biocompatible Poly(ethylene glycol)-blockPoly(ε-caprolactone) Nano-Micelles on the Antifungal Efficacy of Voriconazole. Biointerface Res Appl Chem. 2022;13(1):62.

Ahmad Z, Shah A, Siddiq M, Kraatz H-B. Polymeric micelles as drug delivery vehicles. RSC Adv. 2014;4(33):17028–38.

Patravale VB, Upadhaya PG, Jain RD. Preparation and Characterization of Micelles BT - Pharmaceutical Nanotechnology: Basic Protocols. In: Weissig V, Elbayoumi T, editors. New York, NY: Springer New York; 2019. p. 19–29.

Feng YH, Zhang XP, Li JY, Guo XD. How is a micelle formed from amphiphilic polymers in a dialysis process: Insight from mesoscopic studies. Chem Phys Lett. 2020;754:137711.

Werner ME, Cummings ND, Sethi M, Wang EC, Sukumar R, Moore DT, et al. Preclinical evaluation of Genexol-PM, a nanoparticle formulation of paclitaxel, as a novel radiosensitizer for the treatment of non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2013 Jul 1;86(3):463–8.

Jafar G, Agustin E, Puryani D. Pengembangan formula solid lipid nanoparticles (SLN) Hidrokortison Asetat. J Pharmascience. 2019;6(1):83–96.

Federer C, Spleis HV, Summonte S, Friedl JD, Wibel R, Bernkop-Schnürch A. Preparation and Evaluation of Charge Reversal Solid Lipid Nanoparticles. J Pharm Sci. 2022;

Thakkar A, Chenreddy S, Wang J, Prabhu S. Evaluation of ibuprofen loaded solid lipid nanoparticles and its combination regimens for pancreatic cancer chemoprevention. Int J Oncol. 2015;46(4):1827–34.

Hamishehkar H, Same S, Adibkia K, Zarza K, Shokri J, Taghaee M, et al. A comparative histological study on the skin occlusion performance of a cream made of solid lipid nanoparticles and Vaseline. Res Pharm Sci. 2015 Oct 1;10:378–87.

Duan Y, Dhar A, Patel C, Khimani M, Neogi S, Sharma P, et al. A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems. RSC Adv. 2020;10(45):26777–91.

Silva AC, González-Mira E, García ML, Egea MA, Fonseca J, Silva R, et al. Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound. Colloids Surfaces B Biointerfaces. 2011;86(1):158–65.

Li Y, Dong L, Jia A, Chang X, Xue H. Preparation of solid lipid nanoparticles loaded with traditional Chinese medicine by high-pressure homogenization. Nan Fang Yi Ke Da Xue Xue Bao. 2006 May;26(5):541–4.

Butani D, Yewale C, Misra A. Topical Amphotericin B solid lipid nanoparticles: Design and development. Colloids Surf B Biointerfaces. 2016 Mar;139:17–24.

Singh AK, Garg G, Sharma PK. NANOSPHERES: A NOVEL APPROACH FOR TARGETED DRUG DELIVERY SYSTEM. In 2010.

Guterres SS, Alves MP, Pohlmann AR. Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights. 2007/07/11. 2007;2:147–57.

Pippa N, Demetzos C, Pispas S. Drug Delivery Nanosystems: From Bioinspiration and Biomimetics to Clinical Applications. Jenny Stanford Publishing; 2019.

Deepika MS, Thangam R, Sheena TS, Vimala RT V, Sivasubramanian S, Jeganathan K, et al. Dual drug loaded PLGA nanospheres for synergistic efficacy in breast cancer therapy. Mater Sci Eng C. 2019;103:109716.

Szczepanowicz K, Piechota P, Węglarz WP, Warszyński P. Polyelectrolyte nanocapsules containing iron oxide nanoparticles as MRI detectable drug delivery system. Colloids Surfaces A Physicochem Eng Asp. 2017;532:351–6.

Yang WJ, Zhao T, Zhou P, Chen S, Gao Y, Liang L, et al. “Click” functionalization of dual stimuli-responsive polymer nanocapsules for drug delivery systems11Electronic supplementary information (ESI) available. See DOI: 10.1039/c7py00161d. Polym Chem. 2017;8(20):3056–65.

Trindade IC, Pound-Lana G, Pereira DGS, de Oliveira LAM, Andrade MS, Vilela JMC, et al. Mechanisms of interaction of biodegradable polyester nanocapsules with non-phagocytic cells. Eur J Pharm Sci. 2018;124:89–104.

Yunessnia lehi A, Shagholani H, Ghorbani M, Nikpay A, Soleimani lashkenari M, Soltani M. Chitosan nanocapsule-mounted cellulose nanofibrils as nanoships for smart drug delivery systems and treatment of avian trichomoniasis. J Taiwan Inst Chem Eng. 2019;95:290–9.

Setianty TN, Priani SE, Aryani R. Kajian Metode Pembuatan dan Bahan Penyalut pada Formulasi Nanokapsul Agen Sitotoksik. Pros Farm. 2021;190–7.

Shirode AB, Bharali DJ, Nallanthighal S, Coon JK, Mousa SA, Reliene R. Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention. Int J Nanomedicine. 2015;10:475–84.

Buss JH, Begnini KR, Bruinsmann FA, Ceolin T, Sonego MS, Pohlmann AR, et al. Lapatinib-Loaded Nanocapsules Enhances Antitumoral Effect in Human Bladder Cancer Cell. Front Oncol. 2019 Apr 9;9:203.

Ushirobira C, Afiune L, Pereira M, Cunha Filho M, Gelfuso G, Gratieri T. Dutasteride nanocapsules for hair follicle targeting: Effect of chitosan-coating and physical stimulus. Int J Biol Macromol. 2020 Feb 1;151.

Milosavljevic V, Jamroz E, Gagic M, Haddad Y, Michalkova H, Balkova R, et al. Encapsulation of Doxorubicin in Furcellaran/Chitosan Nanocapsules by Layer-by-Layer Technique for Selectively Controlled Drug Delivery. Biomacromolecules. 2020;21(2):418–34.

Yafout M, Ousaid A, Khayati Y, El Otmani IS. Gold nanoparticles as a drug delivery system for standard chemotherapeutics: A new lead for targeted pharmacological cancer treatments. Sci African. 2021;11:e00685.

Syukri Y, Nugroho BH, Febriana Y, Ningrum ADK, Maharani GA. INOVASI PENGOBATAN ANTIKANKER PAYUDARA DARI NANOPARTIKEL EMAS EKSTRAK DAUN TIN (Ficus carica L.). Khazanah J Mhs. 2020 Sep 5;11(1 SE-Articles).

Hussain MH, Abu Bakar NF, Mustapa AN, Low K-F, Othman NH, Adam F. Synthesis of Various Size Gold Nanoparticles by Chemical Reduction Method with Different Solvent Polarity. Nanoscale Res Lett. 2020;15(1):140.

NIH. No NU-0129 in Treating Patients With Recurrent Glioblastoma or Gliosarcoma Undergoing SurgeryTitle [Internet]. 2020 [cited 2022 Jun 23]. Available from: https://www.clinicaltrials.gov/ct2/show/NCT03020017

nih. ClinicalTrial.gov [Internet]. 2022 [cited 2022 Jul 15]. Available from: https://clinicaltrials.gov/

De Jong WH, Borm PJA. Drug delivery and nanoparticles:applications and hazards. Int J Nanomedicine. 2008;3(2):133–49.

nih. ClinicalTrial.gov [Internet]. 2022

[cited 2022 Jul 15]. Available from:

https://clinicaltrials.gov/

De Jong WH, Borm PJA. Drug delivery

and nanoparticles:applications and

hazards. Int J Nanomedicine.

;3(2):133–49.

Refbacks

  • There are currently no refbacks.