REAKSI SILANG RESPONS IMUN HUMORAL VIRUS A/H1N1 PANDEMI/2009 DAN SEASONAL/2006 PADA REMAJA PERIODE KELAHIRAN TAHUN 1990-1996

Abstract

Abstract

A newest pandemic influenza has emerged, caused by A/H1N1 virus spread rapidly across the world in 2009. The old population born before 1977 had cross-reactive antibodies to pandemic H1N1/2009. The aim of this study was to investigate cross-reactive humoral immune response against pandemic H1N1/2009 and seasonal H1N1/2006 virus in adolescents aged 1218 years born in 19901996 and correlation age or birth and level of cross-reactivity. The cross sectional study was conducted on 131 stored serums from adolescent donors' aged 12–18 years born in 1990-1996. Using a haemagglutination inhibition assay, we measured cross-reactivity based on geometric mean titer (GMT), percentage of seropositive, and seroconversion rate antibodies against pandemic H1N1/2009 after influenza vaccination containing A/Solomon/3/2006(H1N1)-like in Bandung during 2012. Geometric mean titers and percentage of seropositive against pandemic H1N1/2009 virus pre and post-vaccination were not related significantly, p=0.265 and 0.200 respectively. Fifteen subjects (11.5%) had seroconversion. The correlation of pandemic H1N1/2009 and seasonal H1N1/2006 virus seroconversion rate was not significant, p=0.191. There was significant correlation between the age or birth and the cross-reactivity against pandemic H1N1/2009 and seasonal H1N1/2006 virus, p=0.013 and r=0.216. Conclusions, no cross-reactivity against pandemic H1N1/2009 and seasonal H1N1/2006 virus in adolescent age 1218 years born in 19901996, the age or birth was related to the level of cross-reactivity. Earlier birth result the higher cross-reactivity. Influenza vaccination should be done routine and regular by notifying birth period.

Key words: adolescent, birth, cross-reactivity, pandemic influenza 2009