Indonesian Journal of Pharmaceutical Science and Technology
Antidiabetic Potential Screening of Ulin Fruit Extract (Eusideroxylon zwageri) Against Streptozotocin-Induced Diabetic Rats
Abstrak
Empirical evidence of complementary medicine from one community in Kalimantan often uses Ulin fruit (Eusideroxylon zwageri) for medical therapy or as herbal drinks by people with diabetes mellitus. This research aims to identify the antidiabetic compound of Ulin fruit extract against Streptozotocin (STZ) induced diabetic rats. Extraction was performed by maceration method using 96% ethanol, phytochemical test of extracts, extract toxicity test on mice (50 mg/BW to 200 mg/BW), test antidiabetic extract in diabetic rats induced by STZ as much as 70 mg/kgBW with each extract dose of 150, 300, and 600 mg given for 14 days, positive control is Glibenclamide 0.25 mg/kg/day, and the negative control is CMC 1%. Phytochemical test results showed that the extract of Ulin contains alkaloids, tannins, flavonoids, phenolics, terpenoids, and steroids. Ulin fruit extract was not toxic to rats at 50, 150, and 200 mg for three days. Based on the Mann-Whitney test, there was an effect of giving the extract on changes in the average body weight and body temperature of rats during three days of administration (p = 0.000). The results showed novelty that the extract of Ulin fruit affected reducing blood glucose levels in diabetic rats during 14 days of administration (p=0.000).
Keywords: Antidiabetic, Eusideroxylon zwageri, flavonoids, streprozotocin, diabetic rats
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Hosseinzadeh H, Ramezani M, Danael A. Antihyperglycaemic effect and acute toxicity of Securigera securidaca L. seed extracts in mice. Phyther Res. 2002;16:745–7.
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CL M, Q D, CN. Blesso. Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL Function. Adv Nutr. 2017;15(8):226–39.
Buddhakala N, Talubmook C. Toxicity and antidiabetic activity of ethanolic extract of Sphagneticola trilobata (L.) Pruski flower in rats. J Ethnopharmacol. 2020;262(15):113–28.
Florence N, Benoit M, Jonas K, Alexandra T, Désiré D, Pierre K, et al. Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats. J Ethnopharmacol. 2014;151:784–90.
Zhang L, Liu Y, Ke Y, Liu Y, Luo X, Li C, et al. Antidiabetic activity of polysaccharides from Suillellus luridus in streptozotocin-induced diabetic mice. Int J Biol Macromol. 2018;
Wu Y, Ding Y, Tanaka Y, Zhang W. Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention. Int J Med Sci. 2014;11(11):1185–200.
Badan Penelitian dan Pengembangan Kesehatan. Riset Kesehatan Dasar (RISKESDAS) 2013. Lap Nas 2013. 2013;1–384.
Koehn F, Carter G. The evolving role of natural products in drug discovery. Nat Rev Drug Discov. 2005;4:206–20.
Pandit R, Phadke A, Jagtap A. Antidiabetic effect of Ficus religiosa extract in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2010;128:462–6.
Oliveira H, Santos Mp, Grigola R, Lima L, Martins D, Lima J, et al. Antidiabetic activity of Vatairea macrocarpa extract in rats. J Ethnopharmacol. 2008;115:515–9.
Panche A, Diwan A, Chandra S. Falvonoids: an overview. J Nutr Sci. 2016;5(47):1–15.
Osigwe C, Akah P, Nworu C, Okoye F. Apigenin: A methanol fraction component of Newbouldia laevis leaf, as a potential antidiabetic agent. J Phytopharm. 2017;6(1):38–44.
Salehi B, Ata A, Kumar N, Sharopov F, Ram K, Ruiz-ortega A, et al. Antidiabetic Potential of Medicinal Plants and Their Active Components. Biomolecules. 2019;9(551):1–121.
Olaleye M. Cytotoxicity and antibacterial activity of methanolic extract of Hibiscus sabdariffa. J Med Plants Res. 2007;1:9–13.
Brian F, Thomas-Bigger J, Goodman G. The Pharmacological Basis of Therapeutics. Macmillan, New York: NY, USA.; 1985. 7 p.
Bhandary SK, N SK, Bhat VS, Sharmila KP, Bekal MP. Preliminary phytochemical screening of various extracts of punica granatum peel, whole fruit and seeds. 2020;2(4).
Ojewole J. Antinociceptive, anti-inflammatory and antidiabetic effects of Bryophyllum pinnatum (Crassulaceae) leaf aqueous extract. J Ethnopharmacol. 2005;99:13–9.
Szkudelski T, Szkudeska K. Streptozotocin induces lypolysis in rat adipocytes in vitro. Physiol Res. 2002;51:255–9.
Hosseinzadeh H, Ramezani M, Danael A. Antihyperglycaemic effect and acute toxicity of Securigera securidaca L. seed extracts in mice. Phyther Res. 2002;16:745–7.
Ananthan R, Latha M, Ramkumar K, Pari L, Baskar C, Bai V. Effect of Gymnema montanum leaves on serum and tissue lipids in alloxan diabetic rats. Exp Diabetes Res. 2003;4:183–9.
J. Boratyński P, Zielińska-Błajet M, Jacek S. Cinchona Alkaloids—Derivatives and Applications. In: The Alkaloids: Chemistry and Biology. Elsevier Inc.; 2019. p. 29–145.
CL M, Q D, CN. Blesso. Effects of Dietary Flavonoids on Reverse Cholesterol Transport, HDL Metabolism, and HDL Function. Adv Nutr. 2017;15(8):226–39.
Buddhakala N, Talubmook C. Toxicity and antidiabetic activity of ethanolic extract of Sphagneticola trilobata (L.) Pruski flower in rats. J Ethnopharmacol. 2020;262(15):113–28.
Florence N, Benoit M, Jonas K, Alexandra T, Désiré D, Pierre K, et al. Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats. J Ethnopharmacol. 2014;151:784–90.
DOI: https://doi.org/10.24198/ijpst.v1i1.36621
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