The Profile of Antihypertensive Drug Prescriptions and Interactions at Pindad General Hospital
Abstract
Hypertension is a major problem in the world. World Health Organization (WHO) reported that 1.13 billion people in the world suffer from hypertension. This study aimed to determine antihypertensive prescription profile and drug interaction in outpatient installation at PINDAD General Hospital, Bandung in January 2019. This study was non-experimental observational studies with retrospective data collection. There were 381 patients with hypertension (50,13% female and 49,87% male). The most widely used antihypertensive drug is Amlodipine (33,28%) and Calcium Channel Blocker drug (34,20%). Moreover, we found 74,07% was moderate drug-drug interaction (DDI) with Amlodipine and Lisinopril as the most common cases (21,08%). We concluded that 15,7% prescription contain antihypertensive drugs and moderate DDI occurred in the use of amlodipine and lisinopril. DDI should get more attention due to the clinical manifestations that may occur in patients.
Keywords
Full Text:
PDFReferences
Wright JM, Musini VM. First-line drugs for hypertension. Cochrane Database System Reviews. 2009. doi:10.1002/14651858.CD001841.pub2
US Food and Drug Administration. Drug Interactions: What You Should Know. Resour You . 2013;(May):1. https://www.fda.gov/drugs/resourcesforyou/ucm163354.htm.
Daskalopoulou SS, Rabi DM, Zarnke KB, et al. The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension. Canadian Journal of Cardiology. 2015. doi:10.1016/j.cjca.2015.02.016
Rahajeng E, Tuminah S. Prevalence of Hypertension and Its Determinants in Indonesia. Journal of Indonesian Medical Association. 2009.
Hussain MA, Al Mamun A, Reid C, Huxley RR. Prevalence, awareness, treatment and control of hypertension in Indonesian adults aged ≥40 years: Findings from the Indonesia Family Life Survey (IFLS). PLoS One. 2016. doi:10.1371/journal.pone.0160922
Fitriani. Profil Peresepan dan Evaluasi Interaksi Obat Antihipertensi pada Pasien Geriatri di Instalasi Rawat Inap Rumah Sakit Panti Rapih Yogyakarta Tahun 2005. 2007.
Chobanian A V., Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003. doi:10.1161/01.HYP.0000107251.49515.c2
Safar ME. Systolic hypertension in the elderly: Arterial wall mechanical properties and the renin-angiotensin-aldosterone system. Journal of Hypertension. 2005. doi:10.1097/01.hjh.0000163130.39149.fe
Weber MA, Neutel JM, Cheung DG. Hypertension in the aged: A pathophysiologic basis for treatment. American Journal of Cardiology. 1989. doi:10.1016/0002-9149(89)90112-4
Gu Q, Paulose-Ram R, Dillon C, Burt V. Antihypertensive medication use among US adults with hypertension. Circulation. 2006. doi:10.1161/CIRCULATIONAHA.105.542290
Naidu MUR, Usha PR, Rao TRK, Shobha JC. Evaluation of amlodipine, lisinopril, and a combination in the treatment of essential hypertension. Postgraduate Medical Journal. 2000. doi:10.1136/pmj.76.896.350
Cappuccio FP, Markandu ND, Singer DR MG. Amlodipine and lisinopril in combination for the treatment of essential hypertension: efficacy and predictors of response. Journal of Hypertension. 1993;11(8):839-847. doi:10.1097/00004872-199308000-00011
Marquito AB atist., Fernandes NM da S, Colugnati FA ntoni. B, de Paula RB. Identifying potential drug interactions in chronic kidney disease patients. Journal of Brasilian Nefrology. ʹorgão Of Soc Bras e Latino-Americana Nefrol. 2014. doi:10.5935/0101-2800.20140006
Stockley’s drug interactions: a source book of interactions, their mechanisms, clinical importance and management. Choice Reviews Online. 2010. doi:10.5860/choice.48-1222
DOI: https://doi.org/10.15416/pcpr.v5i1.26172
Refbacks
- There are currently no refbacks.
