Correlation of odontogenic infection severity score with C-reactive protein levels on patients with odontogenic infection in Dr Hasan Sadikin General Hospital Bandung

Ariyaka Niastya Prihandana, Harmas Yazid Yusuf, Agus Nurwiadh, Leni Lismayanti

Abstract


Introduction:  Head and neck infections commonly caused by spreading odontogenic infection, which able to cause a local and systemic manifestation, from mild to severe complications according to its severity. Assessment of the severity of odontogenic infections is essential to determine the prognosis, assessed through local and systemic parameters. Laboratory examination used to examine the biological marker that indicates the ongoing infection. C-reactive protein (CRP) is a protein synthesised by hepatocytes in response to the body's inflammatory process, including odontogenic infection. This study was aimed to analyse the severity score of odontogenic infections using the CRP levels in patients with odontogenic infections. Methods: An analytic study with a cross-sectional approach was conducted on 30 patients of Dr Hasan Sadikin General Hospital Bandung diagnosed with odontogenic infections, determined by calculations according to Hosmer and Lemeshow. Assessment of the severity score in odontogenic infections and quantitative CRP levels with the Dimension tool was conducted afterwards. Correlation between odontogenic infection severity score and CRP levels was analysed using regression and correlation tests. Results: From 30 subjects, there was found 33.3% with mild severity score, 63.3% moderate score and 3.3% severe score. The mean of the CRP level was significantly increased according to the odontogenic severity scoring category. All research subjects who were examined showed that there was a very strong and significant correlation (p-value<0.05) between the severity of odontogenic infections and CRP levels in odontogenic infection patients with a correlation coefficient r=0.84 (p=0.001). Conclusion: There is a positive correlation between the CRP levels and the severity score of odontogenic infection. The higher the CRP levels, the odontogenic infection will be more severe. Therefore, the CRP level might be considered an additional biomarker in supporting the severity of odontogenic infection in clinical practice.


Keywords


C-reactive protein; odontogenic infections; severity score

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References


Berkovics C. Local Anesthesis for the Dental Hygienist, handbook of BSc level Dental Hygiene Program. Chapter 2. University of Szeged. 2011. p. 57-62.

Hupp JR, Ellis EI, Tucker MR. Contemporary Oral and Maxillofacial Surgery. 6th ed. St. Louis: Mosby-Elsevier. 2014. p. 296-338.

Han X, An J, Zhang Y, Gong X, He Y. Risk factors for life-threatening complications of maxillofacial space infection. J Craniofac Surg. 2016 Mar;27(2):385-90. DOI: 10.1097/SCS.0000000000002416

Salgado FJ, Arias P. Acute Phase Proteins as Early Non-Specific Biomarkes of Human and Veterinary Diseases, Chapter 7: Acute Phase Proteins as Biomarkers of Disease: From Bench to Clinical Practice. 2011. p. 127-65.

Bali RK, Sharma P, Gaba S, Kaur A, Ghanghas P. A review of complications of odontogenic infections. Natl J Maxxilofac Surg. 2015 Jul-Dec;6(2):136-43. DOI: 10.4103/0975-5950.183867

Gronholm L. Severe Odontogenic Infections. Studies on Local and Systemic Odontogenic Infections Requiring Hospital Care. Academic Dissertation, Medical Faculty of The University Helsinki. 2012. p. 35-40.

Ogle OE. Odontogenic infections. Dent Clin North Am. 2017;61(2):236-52. DOI: 10.1016/j.cden.2016.11.004

Frydman WL, Abbaszadeh K. Diagnosis and Management of Odontogenic Oral and Facial Infections. Oral Health 2014.

Holtmann H, Lommen J, Sander K, Kubler NR, Langie R. Odontogenic cervical necrotizing fasciitis and descending necrotizing mediastinitis in a diabetic patient: literature review and report of a rare and fatal case. World J Oral Maxillofac Surg. 2018;1(1):1-4.

Hargreaves KM, Cohen S. Cohen pathway's of the Pulp, 10th ed. St. Louis: Mosby-Elsevier; 2011. p. 785-820.

Hupp JR, Ferneini EM. Head, Neck, and Orofacial Infections: An Interdisciplinary Approach. 1st ed. St. Louis: Mosby-Elsevier 2016. p. 203-20.

Bali R, Sharma P, Ghanghas P, Gupta N, Tiwari JD, Singh A. To Compare the Efficacy of C-Reactive Protein and Total Leucocyte Count as Markers for Monitoring the Course of Odontogenic, J Maxillofac Oral Surg. 2017 Sept;16(2):322-7. DOI: 10.1007/s12663-016-0978-3

Miloro M, Ghali GE, Larsen PE, Peter D. Peterson’s Principles of Oral and Maxillofacial Surgery – 3rd ed. Connecticut. 2011. p. 841-55.

Sainuddin S, Hague R, Howson K, Clark S. New admission scoring criteria for patients with odontogenic infections: A pilot study. Br J Oral Maxilloc Surg. 2017;55:86-9. DOI: 10.1016/j.bjoms.2016.05.003

Sharma A, Giraddi G, Krishnan G, Shahi AK. Efficacy of serum prealbumin and crp levels as monitoring tools for patients with fascial space infections of odontogenic origin: a clinicobiochemical study, J Maxillofac Oral Surg 2014 Mar;13(1):1-9. DOI: 10.1007/s12663-012-0376-4.

Cowin SC, Cardoso L. Blood and interstitial flow in the hierarchial pore space architecture of bone tissue. J Biomech. 2015 March;48(5):842-54. DOI: 10.1016/j.jbiomech.2014.12.013

Aloitibi N, Cloutier L, Khaldoun E, Bois E, Chirat M, Salvan D. Criteria for admission of odontogenic infections at high risk of deep neck space Infection. Eur Ann Otorhinolaryngology, Head Neck Dis. 2015;132:261-64. DOI: 10.1016/j.anorl.2015.08.007

Mirochnik R, Araidy S, Yaffe V, Abu EI. Severity Score as Prognostic Factors for Management of infection of odontegenic origin, a study of 100 cases. Open J Stomatology. 2017;7:25-34. DOI: 10.4236/ojst.2017.71002

Ziętarska M, Lipiec JK, Kraj L, Zaucha R, Małgorzewicz S. Nutritional status assessment in colorectal cancer patients qualified to systemic treatment. Contemp Oncol (Pozn). 2017;21(2):157-161. DOI: 10.5114/wo.2017.68625.

Heim N, Wiedemeyer V, Reich RH, Martini M, The role of C-reactive protein and white blood cell count in the prediction of length of stay in hospital and severity of odontogenic abscess. J Craniomaxillof Surg 2018;46(12):2220-26. DOI: 10.1016/j.jcms.2018.10.013.

Simon AK, Hollander GA, McMichael A. Evolution of the immune system in humans from infancy to old age. Proc Biol Sci. 2015 Dec 22;282(1821):20143085. DOI: 10.1098/rspb.2014.3085.

Saito CT, Gulinelli JL, Marão HF, Garcia Jr IR, Filho OM, Sonoda CK, et al. Occurrence of odontogenic infections in patients treated in a post graduation program on maxillofacial surgery and traumatology. J Craniofac Surg. 2011;22(5):1689–94. DOI: 10.1097/SCS.0b013e31822e5c8d

Rasteniene R, Puriene A, Aleksejuniene J, Peciuliene V, Zaleckas L. Odontogenic Maxillofacial Infections: A Ten-Year Retrospective Analysis. Surg Infect (Larchmt) 2015:16(3):305-12. DOI: 10.1089/sur.2013.264.

Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front. Immunol. 2018;9:754. DOI: 10.3389/fimmu.2018.00754

Opitz D, Camerer C, Camerer DM, Raguse JD, Menneking H, Hoffmeister B, et al. Incidence and management of severe odontogenic infections-a retrospective analysis from 2004 to 2011. J Craniomaxillofac Surg 2015;43(2):285-9. DOI: 10.1016/j.jcms.2014.12.002

Bagul R, Chandan S, Dilip Sane V , Patil S, Yadav D. Comparative Evaluation of C-Reactive Protein and WBC Count in Fascial Space Infections of Odontogenic Origin. J Maxillofac Oral Surg. 2017 Jun;16(2):238-42. DOI: 10.1007/s12663-016-0953-z.

Savitri R, Karasutisna, Nurwiadh A. Description of odontogenic infection cases at the oral surgery polyclinic of Hasan Sadikin hospital Bandung, Indonesia. Padjadjaran J Dent 2012;24(1):47-52. DOI: 10.24198/pjd.vol24no1.15382.

Bali RK, Sharma P, Gaba S, Kaur A, Ghanghas P. A review of complications of odontogenic infections. Natl J Maxillofac Surg 2015;6:136-43. DOI: 10.4103/0975-5950.183867.

Michael JA, Hibbert SA. Presentation and management of facial swellings of odontogenic origin in children. Eur Arch Paediatr Dent 2014;15(4):259–68. DOI: 10.1007/s40368-014-0110-7

Han Xiaodong, AnJingang, Zhang Yi, Gong Xi, and He Yang, Risk Factors for Life-Threatening Complications of Maxillofacial Space Infection. J Craniofac Surg 2016 Mar;27(2):385-90. DOI: 10.1097/SCS.0000000000002416.




DOI: https://doi.org/10.24198/pjd.vol33no1.21252

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