Clinical appearance of oral lesions in bronchial asthma patients using inhalation drug

Audrey Amber Vieri; Rosiliwati Wihardja; Tenny Setiani Dewi

doi:10.24198/pjd.vol32no3.27472

Clinical appearance of oral lesions in bronchial asthma patients using inhalation drug

Audrey Amber Vieri, Rosiliwati Wihardja, Tenny Setiani Dewi

Abstract

Introduction: Inhalation therapy has become the first-line treatment for bronchial asthma patients. Studies have proved that not all of the inhaled drugs reach the target organ, but mostly are deposited in the mouth and cause local immunosuppressant and decrease saliva secretion. These conditions are closely linked to some adverse effects in the mouth. The purpose of this study was to describe the clinical appearance of oral lesion in bronchial asthma patients using inhalation drugs. Methods: This study was descriptive and conducted on 30 bronchial asthma patients that have been using inhalation drug for at least one year, free of other systemic diseases, not using denture and orthodontic appliances. Oral mucosa was examined, and any oral lesion was recorded. Results: The most number of oral lesions found in patients through clinical examinations were plaque (73.3%), followed by a fissure (36.7%), atrophy (30%), and the least oral lesions found were pigmentation (3.3%), bullae (3.3%), and petechiae (3.3%). The lesions found in patients using inhalation drugs in a range of up to 10 years were found more varyingly. Conclusion: Plaque, fissure, atrophy, pigmentation, bullae, and petechiae are oral lesions that are clinically found in bronchial asthma patients using inhalation drugs.

Keywords

Bronchial asthma; inhalation drug; oral lesion

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References

Ministry of Health of the Republic of Indonesia. Indonesia Health Profile 2012. Jakarta: Ministry of Health of the Republic of Indonesia; 2013. p. 1–8.

Nalina N, Chandra MRS, Umashankar. Assessment of quality of life in bronchial asthma patients. Int J Med Public Health. 2015; 5(1): 93–7. DOI: 10.4103/2230-8598.151270

National Institute of Health Research and Development (NIHRD). Indonesia Basic Health Research (RISKESDAS) 2017-2018. Jakarta: Ministry of Health of the Republic of Indonesia; 2018. p. 45–50.

Jones GW. The 2010–2035 Indonesian Population Projection - Understanding the Causes, Consequences and Policy Options for Population and Development. Jakarta: UNFPA Indonesia; 2013. p. 24

Keles S, Yılmaz NA. Asthma and its impacts on oral health. Meandros Med Dent J. 2016; 17(1): 35–8. DOI: 10.4274/meandros.2569

Godara N, Godara R, Khullar M. Impact of inhalation therapy on oral health. Lung India. 2011; 28(4): 272–5. DOI: 10.4103/0970-2113.85689

Borghardt JM, Kloft C, Sharma A. Inhaled therapy in respiratory disease: The complex interplay of pulmonary kinetic processes. Can Respir J. 2018; 2018: 1–11. DOI: 10.1155/2018/2732017

Correll PK, Poulos LM, Ampon R, Reddel HK, Marks GB. Respiratory Medication Use in Australia 2003-2013: Treatment of Asthma and COPD. Canberra: Australian Institute of Health and Welfare; 2015. p. 64.

Bozejac BV, Stojšin I, Đurić M, Zvezdin B, Brkanić T, Budišin E, et al. Impact of inhalation therapy on the incidence of carious lesions in patients with asthma and COPD. J Appl Oral Sci. 2017; 25(5): 506–14. DOI: 10.1590/1678-7757-2016-0147

Scichilone N. Asthma control: The right inhaler for the right patient. Adv Ther. 2015; 32(4): 285–92. DOI: 10.1007/s12325-015-0201-9

Abdulameer SA. Knowledge and pharmaceutical care practice regarding inhaled therapy among registered and unregistered pharmacists: An urgent need for a patient-oriented health care educational program in Iraq. Int J Chron Obstruct Pulmon Dis. 2018;13: 879–88. DOI: 10.2147/COPD.S157403

Bjermer L. The importance of continuity in inhaler device choice for asthma and chronic obstructive pulmonary disease. Respiration. 2014; 88(4): 346–52. DOI: 10.1159/000363771

Ghapanchi J, Rezazadeh F, Kamali F, Rezaee M, Ghodrati M, Amanpour S. Oral manifestations of asthmatic patients. J Pak Med Assoc. 2015; 65(11): 1226–7.

Ayinampudi BK, Gannepalli A, Pacha VB, Kumar JV, Khaled S, Naveed MA. Association between oral manifestations and inhaler use in asthmatic and chronic obstructive pulmonary disease patients. J Dr NTR Univ Health Sci. 2016; 5(1): 17–23. DOI: 10.4103/2277-8632.178950

Fuseini H, Newcomb DC. Mechanisms driving gender differences in asthma. Curr Allergy Asthma Rep. 2017; 17(3): 1–15. DOI: 10.1007/s11882-017-0686-1

Zein JG, Erzurum SC. Asthma is different in women. Curr Allergy Asthma Rep. 2015; 15(6): 28. DOI: 10.1007/s11882-015-0528-y

Sinyor B, Perez LC. Pathophysiology of Asthma. Treasure Island: StatPearls Publishing; 2020. p. 1-5.

Kusuda Y, Kondo Y, Miyagi Y, Munemasa T, Hori Y, Aonuma F, et al. Long-term dexamethasone treatment diminishes store-operated Ca2+ entry in salivary acinar cells. Int J Oral Sci. 2019; 11: 1–8. DOI: 10.1038/s41368-018-0031-0

Janahi IA, Rehman A, Baloch NUA. Corticosteroids and Their Use in Respiratory Disorders. In: Al-Kaf AG (ed). Corticosteroids. London: InTech Open; 2018. p. 47–57.

Hsu E, Bajaj T. Beta 2 Agonists Treasure Island: StatPearls Publishing; 2020. p. 1-9.

Khalifa MAAA, Abouelkheir HM, Khodiar SEF, Mohamed GAM. Salivary composition and dental caries among children controlled asthmatics. Egypt J Chest Dis Tuberc. 2014; 63(4): 777–88. DOI: 10.1016/j.ejcdt.2014.05.003

Patil S, Rao RS, Majumdar B, Anil S. Clinical appearance of oral Candida infection and therapeutic strategies. Front Microbiol. 2015; 6: 1–10. DOI: 10.3389/fmicb.2015.01391

Ming SWY, Haughney J, Ryan D, Patel S, Ochel M, D’Alcontres MS, et al. Comparison of adverse events associated with different spacers used with non-extrafine beclometasone dipropionate for asthma. Prim Care Resp Med. 2019; 29(1): 1–8. DOI: 10.1038/s41533-019-0115-0

Nakamura S, Okamoto MR, Yamamoto K, Tsurumoto A, Yoshino Y, Iwabuchi H, et al. The candida species that are important for the development of atrophic glossitis in xerostomia patients. BMC Oral Health. 2017; 17(1): 1–8. DOI: 10.1186/s12903-017-0449-3

Nurdiana, Mardia IS. Relationship between glycemic control and coated tongue in type 2 diabetes mellitus patients with xerostomia. Pesqui Bras Odontopediatria Clin Integr. 2020; 13: 1–8. DOI: 10.4034/pboci.2019.191.126

Lesan S, Goudarzi N, Heidarnazhad H, Hassan GM. Comparison of the prevalence of geographic tongue in asthmatic patients and healthy subjects in Masih Daneshvari Hospital in 2014. J Res Dent Maxillofac Sci. 2017; 2(1): 1–5. DOI: 10.29252/jrdms.2.1.1

Sudarshan R, Vijayabala GS, Samata Y, Ravikiran A. Newer classification system for fissured tongue: An epidemiological approach. J Trop Med. 2015; 2015: 1–4. DOI: 10.1155/2015/262079

Bakhtiari S, Sehatpour M, Mortazavi H, Bakhshi M. Orofacial manifestations of adverse drug reactions: A review study. Clujul Med. 2018; 91(1): 27–36. DOI: 10.15386/cjmed-748

Alawi F. Pigmented lesions of the oral cavity. An update. Dent Clin North Am. 2013; 57(4): 699–710. DOI: 10.1016/j.cden.2013.07.006

Beguerie JR, Gonzalez S. Angina bullosa hemorrhagica: Report of 11 cases. Dermatol Reports. 2014; 6(1): 5-7. DOI: 10.4081/dr.2014.5282

Ye Q, He XO, D’Urzo A. A review on the safety and efficacy of inhaled corticosteroids in the management of asthma. Pulm Ther. 2017; 3: 1–18. DOI: 10.1007/s41030-017-0043-5

DOI: https://doi.org/10.24198/pjd.vol32no3.27472