Antibacterial effect of alpha-mangostin from Garcinia mangostana L against oral streptococci and staphylococci biofilms: a systematic review

Rahmawati Sri Praptiningsih, Widowati Siswomihardjo, Alma Linggar Jonarta, Heribertus Dedy Kusuma Yulianto, Liftia Layyinatus Syifa, Yayun Siti Rochmah, Solachuddin Jauhari Arief Ichwan

Abstract


ABSTRACT 


Introduction:  Interactions among competing bacteria, which inhibit each other's growth to maintain the balance of microorganisms in the biofilm, can influence oral cavity homeostasis. Natural products contain compounds with the potential to combat various diseases, including caries. Alpha-mangostin from Garcinia mangostana L exhibits antibacterial properties against oral streptococci and staphylococci, acting through several mechanisms, including the disruption of peptidoglycan, which ultimately leads to cell brittleness and rupture. This study aims to assess the impact of antibacterial alpha-mangostin on oral streptococci and staphylococci biofilm. Methods: The research methodology employed secondary data collection through a systematic review study. We conducted searches across databases including PubMed, ScienceDirect, and Google Scholar to identify Indonesian and English references encompassing textbooks, research findings, reviews, and internet articles relevant to the topic published between 2014 and 2024. Following a thorough screening process, we selected articles deemed pertinent for inclusion in the review. Subsequently, these articles underwent evaluation for full-text accessibility, language compatibility, and availability of information from the respective journals, resulting in the selection of 20 articles. Result: Analysis was carried out on 20 articles. Ten articles described the effects of alpha-mangosteen's inhibit oral biofilm, 6 articles discussed the effects of alpha-mangosteen's antibacterial activity against Streptococcus mutans and Streptococcus sanguis, 3 article state mechanism alpha-mangostin inhibit membrane enzymes such as F(H+)-ATPase and the phosphoenolpyruvate-sucrose phosphotransferase system on Staphylococcus aureus. Additionally, one article describe inhibition mechanism of aldolase, glyceraldehyde-3-phosphate dehydrogenase, and lactic dehydrogenase on Staphylococcus epidermidis. Conclusion: Alpha-mangostin inhibits and disrupts biofilm defense mechanisms. It possesses antimicrobial properties effective against oral streptococci and staphylococci, including Streptococcus mutans, Streptococcus sanguis, Staphylococcus aureus and Staphylococcus epidermidis. These properties operate through various mechanisms, including enhancing the permeability of bacterial cell walls, ultimately leading to bacterial cell death.


Keywords


oral biofilm, alpha-Mangostin, Gram positive oral bacteria, Streptococcus sanguis, Streptococcus mutans, Staphylococcus aureus, Staphylococcus epidermidis

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References


Tangsuksan P, Srichana T, Kettratad M, Nittayananta W. Antimicrobial and Anti-inflammatory Effects of α-Mangostin Soluble Film. J Int Soc Prev Community Dent. 2022;8(831):34–7. https://doi:10.4103/jispcd.JISPCD_222_21

Nguyen PTM, Falsetta ML, Hwang G, Gonzalez-Begne M, Koo H. Α-Mangostin Disrupts the Development of Streptococcus Mutans Biofilms and Facilitates Its Mechanical Removal. PLoS One. 2015;9(10). https://doi.org/10.1371/journal.pone.0111312

Nittayananta W, Wongwitthayakool P, Srichana T, Setthanurakkul C, Yampuen P, Terachinda P, et al. α-Mangostin and lawsone methyl ether in tooth gel synergistically increase its antimicrobial and antibiofilm formation effects in vitro. BMC Oral Health. 2023;23(1):1–14. https://doi.10.1186/s12903-023-03511-z

Sivaranjani M, Prakash M, Gowrishankar S, Rathna J, Pandian SK, Ravi AV. In vitro activity of alpha-mangostin in killing and eradicating Staphylococcus epidermidis RP62A biofilms. Appl Microbiol Biotechnol. 2017; http://doi.101(8):3349–59.

National Center for Biotechnology Information (2024) [Internet]. PubChem Compound Summary for CID 5281650, Mangostin. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Mangostin.

Sivaranjani M, Leskinen K, Aravindraja C, Saavalainen P, Pandian SK, Skurnik M, et al. Deciphering the antibacterial mode of action of alpha-mangostin on Staphylococcus epidermidis RP62A through an integrated transcriptomic and proteomic approach. Front Microbiol. 2019;10(FEB):1–16. https://doi.org/10.3389/fmicb.2019.00150

Nguyen PTM, Nguyen MTH, Bolhuis A. Inhibition of biofilm formation by alpha-mangostin loaded nanoparticles against Staphylococcus aureus. Saudi J Biol Sci [Internet]. 2021;28(3):1615–21. https://doi.org/10.1016/j.sjbs.2020.11.061

Juntavee A, Ratanathongkam A, Chatchiwiwattana S, Peerapattana J, Nualkaew N, Treesuwan P. The Antibacterial Effects of Apacaries Gel (polyphenol from mangosteen extract) on Streptococcus mutans: An in vitro Study. Int J Clin Pediatr Dent [Internet]. 2015;7(2):77–81. Available from: https://doi: 10.4103/jispcd.JISPCD_222_21

Park SY, Lee JH, Ko SY, Kim N, Kim SY, Lee JC. Antimicrobial activity of α-mangostin against Staphylococcus species from companion animals in vitro and therapeutic potential of α-mangostin in skin diseases caused by S. pseudintermedius. Front Cell Infect Microbiol. 2023;13(May):1–14.https://doi.org/10.3389/fcimb.2023.1203663

Nguyen P, Nguyen M, Quach L, Nguyen L, Quyen D. Antibiofilm activity of alpha-mangostin loaded nanoparticles against Streptococcus mutans. Asian Pac J Trop Biomed. 2020;10(7):325–32.https://doi.org/10.4103/2221-1691.284947

Phuong NTM, Van Quang N, Mai TT, Anh NV, Kuhakarn C, Reutrakul V, et al. Antibiofilm activity of α-mangostin extracted from Garcinia mangostana L. against Staphylococcus aureus. Asian Pac J Trop Med [Internet]. 2017;10(12):1154–60. Available from: https://doi.org/10.1016/j.apjtm.2017.10.022

Munar-Bestard M, Rodríguez-Fernández A, Ramis JM, Monjo M. In Vitro Evaluation of Mangostanin as an Antimicrobial and Biocompatible Topical Antiseptic for Skin and Oral Tissues. ACS Pharmacol Transl Sci. 2024;7(5):1507–17. https://doi.org/10.1021/acsptsci.4c00082

Mahendra J, Kasturi R, Mahendra L. Anticariogenic And Anticarcinogenic Effects Of Garcinia Mangostana Pericarp Extracts On Cariogenic Bacteria And On Cancer Cell Lines With Molecular Docking Study. Int J Pharm Res. 2021;13(02). https://doi.org/10.31838/ijpr/2021.13.02.040

Djamaan A, Putri SD, Agustin R. Formulation of toothgel from mangosteen (Garcinia mangostana L.) pericarp extract purified and its antibacterial activity against bacteria of plaque formation. Der Pharm Lett. 2016;8(2):334–9.

Sidarningsih, Yuliati, Diyatri I, Pratiwi RT, Pongsumae D, Aprilia S. Antibacterial Effect of Metabolites from Stem Cells from Human Deciduous Teeth with Alfa-Mangostin and EGCG on Streptococcus mutans and Staphylococcus aureus. Malaysian J Med Heal Sci. 2024;20(June):151–6.

Nguyen PTM, Vo BH, Tran NT, Van QD. Anti-biofilm activity of α-mangostin isolated from Garcinia mangostana L. Zeitschrift fur Naturforsch - Sect C J Biosci. 2015;70(11–12):313–8. https://doi.org/10.1515/znc-2015-0187

Felix LO, Mishra B, Khader R, Ganesan N, Mylonakis E. In Vitro and In Vivo Bactericidal and Antibiofilm Efficacy of Alpha Mangostin Against Staphylococcus aureus Persister Cells. Front Cell Infect Microbiol. 2022;12(July):1–14. https://doi.org/10.3389/fcimb.2022.898794

Praptiningsih RS, Pratiwi R, Nurafifah TY. Alfa Mangostin Extract (Garcinia Mangostana L) Effectiveness on the Biofilm Thickness Growth of Streptococcus Sanguinis. Odonto Dent J. 2023;10(1):7. doi: http://dx.doi.org/10.30659/odj.10.0.7-14

Janardhanan S, Mahendra J, Girija ASS, Mahendra L, Priyadharsini V. Antimicrobial effects of Garcinia mangostana on cariogenic microorganisms. J Clin Diagnostic Res. 2017;11(1):ZC19–22. https://doi.org/10.7860/JCDR/2017/22143.9160

Sultan OS, Kantilal HKA, Phaik KS, Choudhury H, Davamani F. Formulation and Characterization of a Novel Palm-Oil-Based α-Mangostin Nano-Emulsion (PO-AMNE) as an Antimicrobial Endodontic Irrigant: An In Vitro Study. Processes. 2023;11(3).https://doi.org/10.3390/pr11030798

Widyarman AS, Lay SH, Wendhita IP, Tjakra EE, Murdono FI, Binartha CTO. Indonesian Mangosteen Fruit (Garcinia mangostana L.) Peel Extract Inhibits Streptococcus mutans and Porphyromonas gingivalis in Biofilms In vitro. Contemp Clin Dent. 2018;9(11–9):120–5. http:// doi.10.4103/ccd.ccd_758_18




DOI: https://doi.org/10.24198/pjd.vol36no2.53957

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