Microcrystalline Cellulose Isolated from Rami (Boehmeria nivea L. Gaud) used as a Disintegrant in Dimenhydrinate Tablets
Abstract
Microcrystalline cellulose was isolated from rami (Boehmeria Nivea L. Gaud), and applied as disintegrant in tablets of dimenhydrinate, made by direct compression and wet granulation. The aim of this study is to produce dimenhydrinate tablets with Microcrystalline Cellulose Rami (MCC Rami) isolated from Rami (Boehmeria Nivea L. Gaud), as a disintegrant and assess the effect of MCC Rami and Granulation technique on physical properties of drug such as, disintegration time, drug release and dissolution. Formulations of dimenhydrinate 100mg tablets were prepared with a combination of mannitol and lactose as a filler and MCC Rami as disintegrant in a concentration of 10-20%. The formulas were directly compressed or were compressed into tablets after wet granulation. The mechanical properties, drug release, physical properties and effects of process parameters, methods of applying disintegrant in tablet formulas were examined. A significant difference in disintegration time of tablets that were produced by direct compression and wet granulation was seen, that can be attributed to the porous structure of granules that enhanced fast disintegration, which had eventually improved dissolution and drug release. F1 and F2 with MCC Rami and physical mixture of MCC Rami with crosspovidone as a disintegrant that were directly compressed disintegrated in 79 and 72 seconds respectively thats not a significant difference, however when MCC was applied in an intragranular way its disintegration time is 67 seconds. The results showed that the method of disintegrant application and press of tableting has a significant effect on drug release and dissolution.
Keywords : Microcrystalline Cellulose, wet granulation, disintegrant, Boehmeria Nivea L. Gaud.
References
Thoorens G, Krier F, Leclercq B, Carlin B, Evrard B. Microcrystalline cellulose , a direct compression binder in a quality by design environment — A review. Elsevier BV. 2014;
Thoorens G, Krier F, Rozet E, Carlin B, Evrard B. Understanding the impact of microcrystalline cellulose physicochemical properties on tabletability. Int J Pharm. 2015;490(1–2):47–54.
Dutta R, Nath Y, Ochubiojo ME, Kumar A. Colloids and Surfaces B : Biointerfaces Extraction and characterization of microcrystalline cellulose from fodder grass ; Setaria glauca ( L ) P . Beauv , and its potential as a drug delivery vehicle for isoniazid , a first line antituberculosis drug. Colloids Surfaces B Biointerfaces. 2013;108:85–9.
Kale RD, Shobha P, Vikrant B. Extraction of Microcrystalline Cellulose from Cotton Sliver and Its Comparison with Commercial Microcrystalline Cellulose. J Polym Environ. 2017;0(0):0.
Pate NK, Upadhyay AH, Bergum JS, Reier E. An evaluation of microcrystalline cellulose and lactose excipients using an instrumented single station tablet press. 1994;5173(94).
Mostafa, H.F., Ibrahim, M.A., Sakr A. Development and optimization of dextromethorphan hydrobromide oral disintegrating tablets: effect of formulation and process variables. Pharm Dev Technol. 2013;(18):454–463.
Development D, Pharmacy I. COMPARATIVE TABLETING PROPERTIES OF SIXTEEN. 1987;13:1847–75.
Gamble JF, Chiu W, Tobyn M. Investigation into the impact of sub-populations of agglomerates on the particle size distribution and flow properties of conventional microcrystalline cellulose grades. 2011;16(May 2010):542–8.
Ramana B V, Murthy TEGK. International Journal of Medicine and Open Access Formulation and Comparative Evaluation of Pioglitazone Fast Disintegrating Tablets Prepared by Dry and Wet Granulation Techniques. 2016;4(5):252–61.
Bilac H, Guler E. Studies on controlled release dimenhydrinate from matrix tablet formulations. 1999;
Singh V, Kumar L, Meel RK. Research Article Formulation and Development of Sustained Release Matrix Tablet of Ranolazine. 2014;3(11):22–32.
Wang S, Li J, Lin X, Feng Y, Kou X, Babu S, et al. Novel coprocessed excipients composed of lactose, HPMC, and PVPP for tableting and its application. Int J Pharm. 2015;486(1–2):370–9.
Ogaji. Film coating potential of okra gum using paracetamol tablets as a model drug. Asian J Pharm. 2010;4(2):130.
Chowdary KPR, Enturi V, Pallavi T V. Formulation Development of Etoricoxib Tablets by Wet Granulation and Direct Compression Methods Employing Starch Phosphate- A New Modified Starch. 2011;3(6):163–72.
Jaya S, K.P.R. C, Rao PR. Effect of Binders on the Dissolution Rate and Dissolution Efficiency of Ritonavir Tablets. 2012;2(Iv):109–13.
Ofdimenhydrinate E, Tablets MD. FORMULATION AND EVALUATION OFDIMENHYDRINATE. 2015;4(9):1123–34.
Evaluation of Coprocessed Disintegrants Produced From Tapioca Starch and Mannitol in Orally Disintegrating Paraceta .... 2014;(September).
Shirsand SB, Para MS, Ramani RG, Swamy P V., Kumar DN, Rampure M V. Novel co-processed superdisintegrants in the design of fast dissolving tablets. Int J PharmTech Res. 2010;2(1):222–7.
Swamy et al. Design and characterization of oral dispersible tablets of enalapril maleate using a co-processed excipient. J Appl Pharm Sci. 2012;2(11):40–9.
Pezeshki SS, Jafariazar Z, Mortazavi SA. Formulation and physicochemical evaluation of dimenhydrinate Oral Fast Dissolving Film . 2014;20(Supp 1):2014.
Shah N, Dalvadi H, Naik P, Desai A, Patel N. Formulation and Evaluation of Immediate Release Tablet of Cinnarizine and Dimenhydrinate. Int J Pharma Sci Res. 2016;7(December):185–9.
Nawangsari D, Chaerunisaa AY, Abdassah M, Sriwidodo S, Rusdiana T, Apriyanti L. Isolation and Physicochemical Characterization of Microcristalline Cellulose from Ramie (Boehmeria nivea L. Gaud) Based on Pharmaceutical Grade Quality. Indones J Pharm Sci Technol J Homepage. 2018;5(2):55–61.
Setty CM, Radhika M, Gupta VRM, Reddy MVR, Jithan A V. Effect of Tablet Processing and Formulation Factors on Disintegration and Dissolution of Aceclofenac Tablets Effect of Tablet Processing and Formulation Factors on Disintegration and Dissolution of Aceclofenac Tablets ABSTRACT : 2011;(January).
Refbacks
- There are currently no refbacks.
