Formulation and Characterization of Tretinoin Nanostructured Lipid Carriers Using Apifil and Cremophore

Garnadi Jafar, Al-fira Putriyanti, Soni Muhsinin

Abstract

The most widely used vitamin A derivative for mild to severe acne is tretinoin. However, it is lipophilic (LogP 6.3). Tretinoin must be transformed into liquid lipids and NLC (nanostructured lipid carriers) based on Apifil® and stabilized by surfactants to address permeability and stability concerns. Heat homogenization and sonication with a sonicator probe were used to formulate tretinoin into NLC. Apifil®, Myritol®, and Chremophore® RH 40 were the materials utilized. Particle size, polydispersity index, zeta potential, adsorption effectiveness, and morphological measurements were then used to describe NLC. The characterization results showed that NLC tretinoin has a particle size of <200 nm for 2 measurements over 30 days, a polydispersity index value of 0.5, a zeta potential range of -7 mV to -19.3 mV, and an efficiency entrapment value of >80% for all formulas. Spherical shape emerged from the morphology data. Conclusion: The findings demonstrate that tretinoin's nanostructured lipid carriers provide favorable characterization outcomes.

 

Keywords: Diabetes, Metformin HCl, Extended release, Direct compressed,
                    Hypromellose, Carboxymethylcellulose natrium.

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DOI: https://doi.org/10.24198/idjp.v5i3.54349

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