Towards Standardized Hydration Testing Protocols for Natural Product-Based Nanoemulgel Moisturizers: A Systematic Review

Benni Iskandar, Sandry Eka Saputri Nst, Debora Inggrid. P, Rosi Ami Sari, Afriani Pulpa Susila

Abstract

The growing complexity of moisturizer formulations, particularly those incorporating natural product-based nanoemulgels, highlights an urgent need for standardized efficacy evaluation methods. This systematic review critically examines hydration testing methodologies used for natural ingredient-based nanoemulgel moisturizers, with a focus on their validity, reliability, and practical application. Through a comprehensive analysis of 32 peer-reviewed articles published between 2000 and 2023, this study identified several key limitations in current practices, including inconsistent testing conditions, the absence of standardized protocols for assessing natural ingredients, and variability in reporting methods. The findings emphasize the necessity of developing robust, standardized hydration testing protocols tailored specifically for natural product-based nanoemulgels. By addressing these challenges, this study lays the groundwork for optimizing nanoemulgel formulations, ensuring reliable efficacy assessments, and enhancing consumer trust in natural-based skincare products.

 

Keyword: Moisturizer, Nanoemulgel, Natural Product

 

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References

b. Huber and j. Burfeindt, “nanotechnology in cosmetics,” in nanocosmetics, vol. 85, cham: springer international publishing, 2019, pp. 17–25. Doi: 10.1007/978-3-030-16573-4_2.

v. Joshi, k. Kumar, d. Khairya, and d. Teotia, “emulgel as a novel drug delivery system: a comprehensive review,” int. J. Indig. Herbs drugs, vol. 5, no. 10, pp. 94–98, mar. 2020, doi: 10.46956/ijihd.v7i5.354.

j. Gu, y. Gui, l. Chen, g. Yuan, h.-z. Lu, and x. Xu, “use of natural products as chemical library for drug discovery and network pharmacology,” plos one, vol. 8, no. 4, p. E62839, apr. 2013, doi: 10.1371/journal.pone.0062839.

a. V rawlings and c. R. Harding, “moisturization and skin barrier function,” dermatol. Ther., vol. 17, no. S1, pp. 43–48, jan. 2004, doi: 10.1111/j.1396-0296.2004.04s1005.x.

c. Surber and j. Kottner, “skin care products: what do they promise, what do they deliver,” j. Tissue viability, vol. 26, no. 1, pp. 29–36, feb. 2017, doi: 10.1016/j.jtv.2016.03.006.

a. Kogan and n. Garti, “microemulsions as transdermal drug delivery vehicles,” adv. Colloid interface sci., vol. 123–126, pp. 369–385, nov. 2006, doi: 10.1016/j.cis.2006.05.014.

m. S. Algahtani et al., “preparation and characterization of curcumin nanoemulgel utilizing ultrasonication technique for wound healing: in vitro, ex vivo, and in vivo evaluation,” gels, vol. 7, no. 4, p. 213, nov. 2021, doi: 10.3390/gels7040213.

m. R. Donthi, s. R. Munnangi, k. V. Krishna, r. N. Saha, g. Singhvi, and s. K. Dubey, “nanoemulgel: a novel nano carrier as a tool for topical drug delivery,” pharmaceutics, vol. 15, no. 1, p. 164, jan. 2023, doi: 10.3390/pharmaceutics15010164.

s. R. Varma et al., “in vitro anti-inflammatory and skin protective properties of virgin coconut oil,” j. Tradit. Complement. Med., vol. 9, no. 1, pp. 5–14, jan. 2019, doi: 10.1016/j.jtcme.2017.06.012.

j. Garavaglia, m. M. Markoski, a. Oliveira, and a. Marcadenti, “grape seed oil compounds: biological and chemical actions for health,” nutr. Metab. Insights, vol. 9, p. 32910, jan. 2016, doi: 10.4137/nmi.s32910.

n. Pazyar, r. Yaghoobi, m. R. Ghassemi, a. Kazerouni, e. Rafeie, and n. Jamshydian, “jojoba in dermatology: a succinct review,” g. Ital. Di dermatologia e venereol. Organo uff. Soc. Ital. Di dermatologia e sifilogr., vol. 148, no. 6, pp. 687–691.

t. K. Lin, l. Zhong, and j. L. Santiago, “anti-inflammatory and skin barrier repair effects of topical application of some plant oils,” int. J. Mol. Sci., vol. 19, no. 1, p. 70.

p. Viola and m. Viola, “virgin olive oil as a fundamental nutritional component and skin protector,” clin. Dermatol., vol. 27, no. 2, pp. 159–165, mar. 2009, doi: 10.1016/j.clindermatol.2008.01.008.

a. Surjushe, r. Vasani, and d. Saple, “aloe vera: a short review,” indian j. Dermatol., vol. 53, no. 4, pp. 163–166.

a. Baldisserotto et al., “moringa oleifera leaf extracts as multifunctional ingredients for ‘natural and organic’ sunscreens and photoprotective preparations,” molecules, vol. 23, no. 3, p. 664, mar. 2018, doi: 10.3390/molecules23030664.

a. R. Vaughn, a. Branum, and r. K. Sivamani, “effects of turmeric ( curcuma longa ) on skin health: a systematic review of the clinical evidence,” phyther. Res., vol. 30, no. 8, pp. 1243–1264, aug. 2016, doi: 10.1002/ptr.5640.

j. Richardson, j. E. Smith, m. Mcintyre, r. Thomas, and k. Pilkington, “aloe vera for preventing radiation-induced skin reactions: a systematic literature review,” clin. Oncol., vol. 17, no. 6, pp. 478–484.

j. M. Andrade, c. Faustino, c. Garcia, d. Ladeiras, c. P. Reis, and p. Rijo, “rosmarinus officinalis l.: an update review of its phytochemistry and biological activity,” futur. Sci. Oa, vol. 4, no. 4, p. 283, apr. 2018, doi: 10.4155/fsoa-2017-0124.

j. K. Srivastava, e. Shankar, and s. Gupta, “chamomile: a herbal medicine of the past with a bright future,” mol. Med. Rep., vol. 3, no. 6, pp. 895–901.

p. K. Mukherjee, n. K. Nema, n. Maity, and b. K. Sarkar, “phytochemical and therapeutic potential of cucumber,” fitoterapia, vol. 84, pp. 227–236, jan. 2013, doi: 10.1016/j.fitote.2012.10.003.

s. Kappally, a. Shirwaikar, and a. Shirwaikar, “coconut oil–a review of potential applications,” hygeia jd med, vol. 7, no. 2, pp. 34–41, doi: 10.15254/h.j.d.med.7.2015.149.

j. Garavaglia, m. M. Markoski, a. Oliveira, and a. Marcadenti, “grape seed oil compounds: biological and chemical actions for health,” nutr. Metab. Insights, vol. 9, p. 32910.

t.-k. Lin, l. Zhong, and j. Santiago, “anti-inflammatory and skin barrier repair effects of topical application of some plant oils,” int. J. Mol. Sci., vol. 19, no. 1, p. 70, dec. 2017, doi: 10.3390/ijms19010070.

y. Bensouda, k. Qiraouani boucetta, z. Charrouf, h. Aguenaou, and a. Derouiche, “the effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity,” clin. Interv. Aging, p. 339, jan. 2015, doi: 10.2147/cia.s71684.

s. G. Danby et al., “effect of olive and sunflower seed oil on the adult skin barrier: implications for neonatal skin care,” pediatr. Dermatol., vol. 30, no. 1, pp. 42–50, jan. 2013, doi: 10.1111/j.1525-1470.2012.01865.x.

d. I. Sánchez-machado, j. López-cervantes, r. Sendón, and a. Sanches-silva, “aloe vera : ancient knowledge with new frontiers,” trends food sci. Technol., vol. 61, pp. 94–102, mar. 2017, doi: 10.1016/j.tifs.2016.12.005.

a. T. Oyeyinka and s. A. Oyeyinka, “moringa oleifera as a food fortificant: recent trends and prospects,” j. Saudi soc. Agric. Sci., vol. 17, no. 2, pp. 127–136, apr. 2018, doi: 10.1016/j.jssas.2016.02.002.

s. Hewlings and d. Kalman, “curcumin: a review of its effects on human health,” foods, vol. 6, no. 10, p. 92, oct. 2017, doi: 10.3390/foods6100092.

d. P. Richardson, j. Ansell, and l. N. Drummond, “the nutritional and health attributes of kiwifruit: a review,” eur. J. Nutr., vol. 57, no. 8, pp. 2659–2676, dec. 2018, doi: 10.1007/s00394-018-1627-z.

l. M. De macedo et al., “rosemary (rosmarinus officinalis l., syn salvia rosmarinus spenn.) And its topical applications: a review.,” plants (basel, switzerland), vol. 9, no. 5, may 2020, doi: 10.3390/plants9050651.

s. Miraj and s. Alesaeidi, “a systematic review study of therapeutic effects of matricaria recuitta chamomile (chamomile),” electron. Physician, vol. 8, no. 9, pp. 3024–3031, sep. 2016, doi: 10.19082/3024.

e. Berardesca, m. Loden, j. Serup, p. Masson, and l. M. Rodrigues, “the revised eemco guidance for the in vivo measurement of water in the skin,” ski. Res. Technol., vol. 24, no. 3, pp. 351–358, aug. 2018, doi: 10.1111/srt.12599.

s. Cho et al., “dietary aloe vera supplementation improves facial wrinkles and elasticity and it increases the type i procollagen gene expression in human skin in vivo,” ann. Dermatol., vol. 21, no. 1, p. 6, 2009, doi: 10.5021/ad.2009.21.1.6.

j. Richardson, j. E. Smith, m. Mcintyre, r. Thomas, and k. Pilkington, “aloe vera for preventing radiation-induced skin reactions: a systematic literature review,” clin. Oncol., vol. 17, no. 6, pp. 478–484, sep. 2005, doi: 10.1016/j.clon.2005.04.013.

m. S. Alam, m. S. Ali, n. Alam, m. R. Siddiqui, m. Shamim, and m. M. Safhi, “in vivo study of clobetasol propionate loaded nanoemulsion for topical application in psoriasis and atopic dermatitis,” drug invent. Today, vol. 5, no. 1, pp. 8–12, mar. 2013, doi: 10.1016/j.dit.2013.02.001.

a. Surjushe, r. Vasani, and d. Saple, “aloe vera: a short review,” indian j. Dermatol., vol. 53, no. 4, p. 163, 2008, doi: 10.4103/0019-5154.44785.

s. Prasad and b. B. Aggarwal, “turmeric, the golden spice. Herbal medicine: biomolecular and clinical aspects,” 2011, turmeric, the golden spice. Crc press/taylor & francis.

s. Jadoon et al., “anti-aging potential of phytoextract loaded-pharmaceutical creams for human skin cell longetivity,” oxid. Med. Cell. Longev., vol. 2015, no. 1, pp. 1–17, 2015, doi: 10.1155/2015/709628.

DOI: https://doi.org/10.24198/idjp.v6i1.59266

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