Tinjauan Mengenai Fisiologi Bursa Fabricius pada Ayam

Muhammad Rifqi Ismiraj

Abstract


Bursa Fabricius merupakan salah satu organ yang penting dalam imunitas ayam. Telah dilaporkan sebelumnya bahwa pembentukan antibody pada ayam berlangsung secara intensif oleh sel B limfosit pada bursa Fabricius. Artikel tinjauan ini mengulas mengenai peran bursa Fabricius dalam tubuh ayam, perkembangannya selama masa embriogenesis, dan perkembangannya setelah masa penetasan. Selain itu, dibahas pula mengenai karakteristik immunoglobulin pada ayam beserta dengan peranannya dalam membangun imunitas tubuh ayam. Artikel tinjauan ini juga mengulas perbandingan antara mekanisme pembentukan antibodi pada ayam dengan hewan pengerat, primata, dan mamalia. Artikel tinjauan ini bertujuan untuk merekam dan menyarikan berbagai laporan hasil penelitian dalam cakupan fisiologi organ bursa Fabricius pada ayam.


References


Ackerman, G.A., and R.A. Knouff. 1959. Lymphocytopoiesis in the bursa of Fabricius. Am. J. Anat. 104:163–205. doi:https://doi.org/10.1002/aja.1001040202.

Aliahmad, P., K.A. Pike, and M.J.H. Ratcliffe. 2005. Cell surface immunoglobulin regulated checkpoints in chicken B cell development. Vet. Immunol. Immunopathol. 108:3–9. doi:https://doi.org/10.1016/j.vetimm.2005.08.009.

Bockman, D.E., and M.D. Cooper. 1973. Pinocytosis by epithelium associated with lymphoid follicles in the bursa of fabricius, appendix, and Peyer’s patches. An electron microscopic study. Am. J. Anat. 136:455–477. doi:https://doi.org/10.1002/aja.1001360406.

Dahan, A., C.-A. Reynaud, and J.-C. Weill. 1983. Nucleotide sequence of the constant region of a chicken μ heavy chain immonoglobulin mRNA. Nucleic Acids Res. 11:5381–5389. doi:10.1093/nar/11.16.5381.

Dieterlen-Lievre, F. 1987. Hemopoietic Cell Progenitors in the Avian Embryo: Origin and Migrations. Ann. N. Y. Acad. Sci. 511:77–87. doi:https://doi.org/10.1111/j.1749-6632.1987.tb36239.x.

Le Douarin, N.M., F. Dieterlen-Lièvre, and P.D. Oliver. 1984. Ontogeny of primary lymphoid organs and lymphoid stem cells. Am. J. Anat. 170:261–299. doi:https://doi.org/10.1002/aja.1001700305.

Glick, B., T.S. Chang, and R.G. Jaap. 1956. The Bursa of Fabricius and Antibody Production. Poult. Sci. 35:224–225. doi:https://doi.org/10.3382/ps.0350224.

Godin, E., J.A. Garcia-porrerot, A. Coutinho, and F. Dleterlen-lievre. 1993. Early Mouse Embryos Contains 364:67–70.

Golovkina, T. V, M. Shlomchik, L. Hannum, and A. Chervonsky. 1999. Organogenic Role of B Lymphocytes in Mucosal Immunity. Science (80-. ). 286:1965 LP – 1968. doi:10.1126/science.286.5446.1965.

Grupp, S.A., K. Campbell, R.N. Mitchell, J.C. Cambier, and A.K. Abbas. 1993. Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma.. J. Biol. Chem. 268:25776–25779.

Hardy, R.R., Y.-S. Li, D. Allman, M. Asano, M. Gui, and K. Hayakawa. 2000. B-cell commitment, development and selection. Immunol. Rev. 175:23–32. doi:https://doi.org/10.1111/j.1600-065X.2000.imr017517.x.

Houssaint, E., A. Toraño, and J. Ivanyi. 1983. Ontogenic restriction of colonization of the bursa of Fabricius. Eur. J. Immunol. 13:590–595. doi:https://doi.org/10.1002/eji.1830130715.

Humphrey, B.D., C.C. Calvert, and K.C. Klasing. 2004. The ratio of full length IgY to truncated IgY in immune complexes affects macrophage phagocytosis and the acute phase response of mallard ducks (Anas platyrhynchos). Dev. Comp. Immunol. 28:665–672. doi:https://doi.org/10.1016/j.dci.2003.11.003.

Lassila, O. 1989. Emigration of B cells from chicken bursa of Fabricius. Eur. J. Immunol. 19:955–958. doi:https://doi.org/10.1002/eji.1830190527.

Leslie, G.A., and L.W. Clem. 1969. PHYLOGENY OF IMMUNOGLOBULIN STRUCTURE AND FUNCTION : III. IMMUNOGLOBULINS OF THE CHICKEN . J. Exp. Med. 130:1337–1352. doi:10.1084/jem.130.6.1337.

Leslie, G.A., and L.N. Martin. 1973. Studies on the Secretory Immunologic System of Fowl. J. Immunol. 110:1 LP – 9.

Li, Y.-S., R. Wasserman, K. Hayakawa, and R.R. Hardy. 1996. Identification of the Earliest B Lineage Stage in Mouse Bone Marrow. Immunity 5:527–535. doi:https://doi.org/10.1016/S1074-7613(00)80268-X.

Magor, K.E., D.A. Higgins, D.L. Middleton, and G.W. Warr. 1994. One gene encodes the heavy chains for three different forms of IgY in the duck.. J. Immunol. 153:5549 LP – 5555.

Mansikka, A. 1992. Chicken IgA H chains. Implications concerning the evolution of H chain genes.. J. Immunol. 149:855 LP – 861.

Motyka, B., and J.D. Reynolds. 1991. Apoptosis is associated with the extensive B cell death in the sheep ileal Peyer’s patch and the chicken bursa of Fabricius: A possible role in B cell selection. Eur. J. Immunol. 21:1951–1958. doi:https://doi.org/10.1002/eji.1830210825.

Paramithiotis, E., K.A. Jacobsen, and M.J. Ratcliffe. 1995. Loss of surface immunoglobulin expression precedes B cell death by apoptosis in the bursa of Fabricius.. J. Exp. Med. 181:105–113. doi:10.1084/jem.181.1.105.

Paramithiotis, E., and J.H.R. Michael. 1994. B cell emigration directly from the cortex of lymphoid follicles in the bursa of Fabricius. Eur. J. Immunol. 24:458–463. doi:https://doi.org/10.1002/eji.1830240229.

Parvari, R., A. Avivi, F. Lentner, E. Ziv, S. Tel-Or, Y. Burstein, and I. Schechter. 1988. Chicken immunoglobulin gamma-heavy chains: limited VH gene repertoire, combinatorial diversification by D gene segments and evolution of the heavy chain locus.. EMBO J. 7:739–744. doi:https://doi.org/10.1002/j.1460-2075.1988.tb02870.x.

Pike, K.A., E. Baig, and M.J.H. Ratcliffe. 2004. The avian B-cell receptor complex: distinct roles of Igα and Igβ in B-cell development. Immunol. Rev. 197:10–25. doi:https://doi.org/10.1111/j.0105-2896.2004.0111.x.

Pike, K.A., and M.J.H. Ratcliffe. 2002. Cell surface immunoglobulin receptors in B cell development. Semin. Immunol. 14:351–358. doi:https://doi.org/10.1016/S1044-5323(02)00068-4.

Pospisil, R., G.O. Young-Cooper, and R.G. Mage. 1995. Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits. Proc. Natl. Acad. Sci. 92:6961 LP – 6965. doi:10.1073/pnas.92.15.6961.

Ratcliffe, M.J.H. 1996. Chicken immunoglobulin isotypes and allotypes. Weir’s Handb. Exp. Immunol. 5th ed., LA Herzenberg, DM Weir, C. Blackwell (eds.). Blackwell Sci. Cambridge, UK 241–247.

Ratcliffe, M.J.H. 2006. Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development. Dev. Comp. Immunol. 30:101–118. doi:https://doi.org/10.1016/j.dci.2005.06.018.

Reynaud, C.-A., V. Anquez, H. Grimal, and J.-C. Weill. 1987. A hyperconversion mechanism generates the chicken light chain preimmune repertoire. Cell 48:379–388. doi:10.1016/0092-8674(87)90189-9.

Reynaud, C.-A., V. Anquez, and J.-C. Weill. 1991. The chicken D locus and its contribution to the immunoglobulin heavy chain repertoire. Eur. J. Immunol. 21:2661–2670. doi:https://doi.org/10.1002/eji.1830211104.

Reynaud, C.-A., A. Dahan, V. Anquez, and J.-C. Weill. 1989. Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region. Cell 59:171–183. doi:https://doi.org/10.1016/0092-8674(89)90879-9.

Reynaud, C.A., B.A. Imhof, V. Anquez, and J.C. Weill. 1992. Emergence of committed B lymphoid progenitors in the developing chicken embryo.. EMBO J. 11:4349–4358. doi:https://doi.org/10.1002/j.1460-2075.1992.tb05534.x.

Reynolds, J.D. 1987. Mitotic rate maturation in the Peyer’s patches of fetal sheep and in the bursa of Fabricius of the chick embryo. Eur. J. Immunol. 17:503–507. doi:https://doi.org/10.1002/eji.1830170411.

Sanchez, M., Z. Misulovin, A.L. Burkhardt, S. Mahajan, T. Costa, R. Franke, J.B. Bolen, and M. Nussenzweig. 1993. Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.. J. Exp. Med. 178:1049–1055. doi:10.1084/jem.178.3.1049.

Sayegh, C.E., S.L. Demaries, K.A. Pike, J.E. Friedman, and M.J.H. Ratcliffe. 2000. The chicken B-cell receptor complex and its role in avian B-cell development. Immunol. Rev. 175:187–200. doi:https://doi.org/10.1111/j.1600-065X.2000.imr017507.x.

Sayegh, C.E., G. Drury, and M.J.H. Ratcliffe. 1999. Efficient antibody diversification by gene conversion in vivo in the absence of selection for V(D)J-encoded determinants. EMBO J. 18:6319–6328. doi:https://doi.org/10.1093/emboj/18.22.6319.

Sayegh, C.E., and M.J.H. Ratcliffe. 2000. Perinatal Deletion of B Cells Expressing Surface Ig Molecules That Lack V(D)J-Encoded Determinants in the Bursa of Fabricius Is Not Due to Intrafollicular Competition. J. Immunol. 164:5041 LP – 5048. doi:10.4049/jimmunol.164.10.5041.

Schaffner, T., J. Mueller, M.W. Hess, H. Cottier, B. Sordat, and C. Ropke. 1974. The bursa of fabricius: A central organ providing for contact between the lymphoid system and intestinal content. Cell. Immunol. 13:304–312. doi:https://doi.org/10.1016/0008-8749(74)90247-0.

Silverman, G.J. 1992. Human Antibody Responses to Bacterial Antigens: Studies of a Model Conventional Antigen and a Proposed Model B Cell Superantigen. Int. Rev. Immunol. 9:57–78. doi:10.3109/08830189209061783.

Sorvari, T., R. Sorvari, P. Ruotsalainen, A. Toivanen, and P. Toivanen. 1975. Uptake of environmental antigens by the bursa of Fabricius. Nature 253:217–219. doi:10.1038/253217a0.

Taylor, R.L., and F.M. McCorkle. 2009. A landmark contribution to poultry science—Immunological function of the bursa of Fabricius12. Poult. Sci. 88:816–823. doi:https://doi.org/10.3382/ps.2008-00528.




DOI: https://doi.org/10.24198/jsdh.v1i1.31372

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