A review of bioactive compounds of Caesalpinia sappan: Pre- and post-harvest effect

Annisa Lugina Rachman, Santi Rosniawaty, Syariful Mubarok, Cucu Suherman, Yudithia Maxiselly

Abstract


Sappanwood (Caesalpinia sappan L.) is a shrub or small tree that thrives in tropical regions and has been widely distributed across various areas. It has long been used as a natural dye in textiles, cosmetics, and herbal beverages due to its content of various bioactive compounds. This literature review discusses the secondary metabolites in sappanwood, their health benefits, and strategies to enhance product quality through pre-harvest and post-harvest treatments. This literature review was conducted by searching for relevant journals on Google Scholar using relevant keywords. Sappanwood contains diverse secondary metabolites, including flavonoids, phenolics, anthraquinones, triterpenoids, steroids, alkaloids, and tannins, with the heartwood generally having the highest concentration, particularly of brazilin. Various production techniques have been studied to optimize morphological and physiological traits as well as secondary metabolite content, such as adjusting planting density and applying different types of fertilizers. Post-harvest treatments, including drying and blanching, are also critical as they influence product quality and bioactive compound retention.


Keywords


antioxidant; drying; fertilizer; planting density; secondary metabolites

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References


Agustin E, Pratiwi A. 2023. The Utilization of Secang Wood (Caesalpinia sappan L.) Extract Nanoemulsion as Natural Pigment in Lip Cream Preparations. Journal of Drug Delivery and Therapeutics, 13(10): 54–58. https://doi.org/10.22270/jddt.v13i10.6242

Ahammed GJ, Li X. 2022. Hormonal regulation of health-promoting compounds in tea (Camellia sinensis L.). Plant Physiology and Biochemistry, 185: 390–400. https://doi.org/10.1016/j.plaphy.2022.06.021

Ahmad A, Ali H, Khan H, Begam A., Khan S, Ali SS, Ahmad N, Fazal H, Ali M, Hano C, Ahmad N, Abbasi BH. 2020a. Effect of gibberellic acid on production of biomass, polyphenolics and steviol glycosides in adventitious. Plants, 9: 420–434.

Ahmad I, Arifianti AE, Sakti AS, Saputri FC, Mun’im A. 2020b. simultaneous natural deep eutectic solvent-based compounds of Cinnamon bark and Sappan wood as a Dipeptidyl Pepidase IV inhibitor. Molecules, 25: 1–11.

Ahmadi AM, Wulandari RA, Taryono. 2020. Performance of three clones tea (Camellia sinensis L.) seedling on the two different seedling media. Vegetalika, 9(2): 359–372.

Ahmed R, Jeyabalan, G, Jeyabalan JB. 2024. Pharmacognostical Studies on the Leaves of Caesalpinia sappan Linn (Fabaceae). International journal of pharmaceutical quality assurance, 15(02): 917–923. https://doi.org/10.25258/ijpqa.15.2.59

Al-Adawiah AR, Rosniawaty S, Anjarsari IRD. 2023. Respons peningkatan perkecambahan benih dan pertumbuhan bibit tanaman secang (Caesalpinia sappan L.) terhadap penggunaan zat pengatur tumbuh dan media tanam yang berbeda. Jurnal Agrikultura, 66(1): 66–73.

Amarawati GAK, Susanti NMP, Laksmiani NPL. 2019. Aktivitas anti-rheumatoid arthritis dari brazilin dan brazilein secara in silico. Jurnal Kimia, 13(2): 153-158. https://doi.org/10.24843/jchem.2019.v13.i02.p05

Anjarsari IRD. 2023. Potensi penggunaan zat pengatur tumbuh sitokinin dan giberelin pada budidaya teh (Camellia sinensis (L.) O. Kuntze) di Indonesia. Agronomika, 21(1): 20–24.

Arsiningtyas IS. 2021. Antioxidant profile of heartwood and sapwood of Caesalpinia sappan L. tree’s part grown in Imogiri Nature Preserve, Yogyakarta. IOP Conference Series: Earth and Environmental Science, 810(1). https://doi.org/10.1088/1755-1315/810/1/012040

Artati A, Pratama R, Nurisyah N, Asyikin A, Abdullah T, Daswi DR, Dewi R. 2025. Phytochemical testing, antioxidant activity and determination of specific and non-specific parameters of secang wood extract (Caesalpinia sappan L.). Journal of Research in Science Education, 11(2):918–929. https://doi.org/10.29303/jppipa.v11i2.10563

Baiqi AU, Utami PP, Anugrah D, Fauzan AA, Ningsih WS, Rusydi MI. 2019. Improving the quality and quantity of cinnamon drying process using art cave in Lambung Bukit West Sumatra. IOP Conference Series: Materials Science and Engineering, 602(1). https://doi.org/10.1088/1757-899X/602/1/012023

Bashir S, Qayyum MA, Husain A, Bakhsh A, Ahmed N, Hussain MB, Elshikh MS, Alwahibi MS, Almunqedhi BMA, Hussain R, Wang YF, ZhouY, Diao ZH. 2021a. Efficiency of different types of biochars to mitigate Cd stress and growth of sunflower (Helianthus; L.) in wastewater irrigated agricultural soil. Saudi Journal of Biological Sciences, 28(4): 2453–2459. https://doi.org/10.1016/j.sjbs.2021.01.045

Bhaskar R, Xavier LSE, Udayakumaran G, Kumar DS, Venkatesh R, & Nagella P. 2022. Biotic elicitors: a boon for the in-vitro production of plant secondary metabolites. Plant Cell, Tissue and Organ Culture, 149(1-2): 7-24. https://doi.org/10.1007/s11240-021-02131-1

Bhat B, Islam S, Ali A, Sheikh B, Tariq L, Islam S, Dar T. 2020. Role of micronutrients in secondary metabolism of plants, 311-329. https://doi.org/10.1007/978-3-030-49856-6_13

Bukke AN, Shankar PC. 2014. Effect of different plant growth regulators on callus induction in Caesalpinia Sappan L. a medicinal plant. International Journal of Recent Scientific Research, 5(11): 1991–1994.

Calín-Sánchez Á, Lipan L, Cano-Lamadrid M, Kharaghani A, Masztalerz K, Carbonell-Barrachina AA, Figiel A. 2020. Comparison of traditional and novel drying techniques and its effect on quality of fruits, vegetables and aromatic herbs. In Foods 9(9). MDPI AG. https://doi.org/10.3390/foods9091261

Cao Y, Yang Y, Tan Z, Feng X, Tian Z, Liu T, Pan Y, Wang M, Su X, Liang H, Guo S. 2025. Metabolomics combined with photosynthetic analysis reveals potential mechanisms of phenolic compound accumulation in Lonicera japonica induced by nitrate nitrogen supply. International Journal of Molecular Sciences, 26. https://doi.org/10.3390/ijms26094464.

Caretto S, Linsalata V, Colella G, Mita G, Lattanzio V. 2015. Carbon fluxes between primary metabolism and phenolic pathway in plant tissues under stress. International Journal of Molecular Sciences, 16(11): 26378–26394. https://doi.org/10.3390/ijms161125967

Cui Z, Qu L, Zhang Q, Lu F, Liu F. 2024. Brazilin-7-2-butenoate inhibits amyloid β-protein aggregation, alleviates cytotoxicity, and protects Caenorhabditis elegans. International Journal of Biological Macromolecules, 264: 1-11. https://doi.org/10.1016/j.ijbiomac.2024.130695

Cun Z, Zhang J, Hong J, Yang J, Gao L, Hao B, Chen J. 2024. Integrated metabolome and transcriptome analysis reveals the regulatory mechanism of low nitrogen-driven biosynthesis of saponins and flavonoids in Panax notoginseng. Gene. https://doi.org/10.1016/j.gene.2024.148163.

Dapson RW, Bain CL. 2015. Brazilwood, sappanwood, brazilin and the red dye brazilein: From textile dyeing and folk medicine to biological staining and musical instruments. Biotechnic and Histochemistry, 90(6): 401–423. https://doi.org/10.3109/10520295.2015.1021381

de Paula PT, Scatolino MV, de Araújo ACC, de Oliveira AFCF, de Figueiredo ICR, de Assis MR, Trugilho PF. 2019. Assessing proximate composition, extractive concentration, and lignin quality to determine appropriate parameters for selection of superior Eucalyptus Firewood. Bioenergy Research, 12(3): 626–641. https://doi.org/10.1007/s12155-019-10004-x

Deylami MZ, Abdul, Tan CP, Bakar J, Olusegun L. 2016. Effect of blanching on enzyme activity, color changes, anthocyanin stability and extractability of mangosteen pericarp: A kinetic study. Journal of Food Engineering, 178: 12–19. https://doi.org/10.1016/J.JFOODENG.2016.01.001

Dvořák P, Krasylenko Y, Zeiner A, Šamaj J, Takáč T. 2021. Signaling toward reactive oxygen species-scavenging enzymes in plants. In Frontiers in Plant Science, 11: 1-24. https://doi.org/10.3389/fpls.2020.618835

ElGamal R, Song C, Rayan AM, Liu C, Al-Rejaie S, ElMasry G. 2023. Thermal degradation of bioactive compounds during drying process of horticultural and agronomic products: A comprehensive overview. In Agronomy 13(6). MDPI. https://doi.org/10.3390/agronomy13061580

El-Nakhel C, Pannico A, Kyriacou M, Giordano M, De Pascale S, Rouphael Y. 2019. Macronutrient deprivation eustress elicits differential secondary metabolites in red and green-pigmented butterhead lettuce grown in closed soilless system. Journal of the science of food and agriculture. https://doi.org/10.1002/jsfa.9985.

Gorni PH, Pacheco AC, Moro AL, Silva JFA, Moreli RR, de Miranda GR, Pelegrini JM, Spera KD, Bronzel JL. & da Silva RMG. 2020. Salicylic acid foliar application increases biomass, nutrient assimilation, primary metabolites and essential oil content inf Achillea millefolium L. Scientia Horticulturae, 270: 1-9. https://doi.org/10.1016/j.scienta.2020.109436

Hardy Z, Jideani VA. 2017. Foam-mat drying technology: A review. Critical Reviews in Food Science and Nutrition, 57(12): 2560–2572. https://doi.org/10.1080/10408398.2015.1020359

He ZJ, Zhu FY, Li SS, Zhong L, Tan HY, Wang K. 2017. Inhibiting ROS-NF-κB-dependent autophagy enhanced brazilin-induced apoptosis in head and neck squamous cell carcinoma. Food and Chemical Toxicology, 101: 55–66. https://doi.org/10.1016/j.fct.2017.01.002

Hilal B, Khan MM, Fariduddin Q. 2024. Recent advancements in deciphering the therapeutic properties of plant secondary metabolites: phenolics, terpenes, and alkaloids. Plant Physiology and Biochemistry, 211. https://doi.org/10.1016/J.PLAPHY.2024.108674

ICRAF.2023. Agroforestry Tree Database: Caesalpinia sappan. World Agroforestry Centre. https://apps.worldagroforestry.org

Izhar L, Hendri J. 2022. Postharvest standard practices for improving Cinnamon quality product in Kerinci. IOP Conference Series: Earth and Environmental Science, 1024(1). https://doi.org/10.1088/1755-1315/1024/1/012078

Jain D, Bisht S, Parvez A, Singh K, Bhaskar P, Koubouris G. 2024. Effective biotic elicitors for augmentation of secondary metabolite production in medicinal plants. Agriculture (Switzerland), 14(796): 1-24. Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/agriculture14060796

Jakovljević D, Topuzović M, Stanković M. 2019. Nutrient limitation as a tool for the induction of secondary metabolites with antioxidant activity in basil cultivars. Industrial Crops and Products. https://doi.org/10.1016/j.indcrop.2019.06.025

Jamaddar S, Sarkar C, Akter S, Mubarak MS, El-Nashar HAS, El-Shazly M, Islam MT. 2023. Brazilin: An updated literature-based review on its promising therapeutic approaches and toxicological studies. In South African Journal of Botany, 158: 118-132. Elsevier B.V. https://doi.org/10.1016/j.sajb.2023.04.053

Jan R, Asaf S, Numan M, Lubna, Kim KM. 2021. Plant secondary metabolite biosynthesis and transcriptional regulation in response to biotic and abiotic stress conditions. Agronomy, 11(5): 1–31. https://doi.org/10.3390/agronomy11050968

Janku M, Luhová, L, Petrivalský M. 2019. On the origin and fate of reactive oxygen species in plant cell compartments. In Antioxidants, 8(14): 1-15. MDPI. https://doi.org/10.3390/antiox8040105

Jia S, Zhao X, Huang J, Yao X, Xie F. 2025. Phosphorus alleviates cadmium damage by reducing cadmium accumulation and enhancing antioxidant enzymes at the vegetative phase in Soybean. Agronomy, 15(637): 1-19. https://doi.org/10.3390/agronomy15030637

Jie H, Zhao L, Ma Y, Rasheed A, Jie Y. 2023. Integrated transcriptome and metabolome analysis reveal that exogenous gibberellin application regulates lignin synthesis in ramie. Agronomy, 13(6). https://doi.org/10.3390/agronomy13061450

Kannathasan K, Kokila P. 2021. Dyeing of cotton fabric by Caesalpinia sappan aqueous extract at different temperatures and mordants. Current Botany, 12: 188–191. https://doi.org/10.25081/cb.2021.v12.7277

Kashchenko NI, Olennikov DN, Chirikova NK. 2021. Phytohormones and elicitors enhanced the ecdysteroid and glycosylflavone content and antioxidant activity of Silene repens. Applied Sciences (Switzerland), 11:1-14. https://doi.org/10.3390/app112311099

Kaushik B, Sharma J, Yadav K, Kumar P, Shourie A. 2021. Phytochemical properties and pharmacological role of plants: secondary metabolites. Biosciences Biotechnology Research Asia, 18(1): 23–35. https://doi.org/10.13005/bbra/2894

Ke SW, Chen GH, Chen CT, Tzen JTC, Yang CY. 2018. Ethylene signaling modulates contents of catechin and ability of antioxidant in Camellia sinensis. Botanical Studies, 59(1): 1-8. https://doi.org/10.1186/s40529-018-0226-x

Kumari N, Varghese BA, Devi S, Khan MA, Jangra S, Kumar A. 2020. Abiotic elicitation: A tool for producing bioactive compounds. Plant Archives, 20: 2683–2689.

Li K, Wan M, Han M, Yang L. 2025. The response of Panax ginseng root microbial communities and metabolites to nitrogen addition. BMC Plant Biology, 25. https://doi.org/10.1186/s12870-025-07031-6.

Liu J, Liu Y, Wang Y, Abozeid A, Zu YG, Tang ZH. 2017. The integration of GC–MS and LC–MS to assay the metabolomics profiling in Panax ginseng and Panax quinquefolius reveals a tissue- and species-specific connectivity of primary metabolites and ginsenosides accumulation. Journal of Pharmaceutical and Biomedical Analysis, 135: 176–185. https://doi.org/10.1016/j.jpba.2016.12.026

Liwanda N, Nurinayah I, Mubayyinah H, Pratiwi ARR, Wahyuningrum T, Ashari RZ, Aisyah SI, Nurcholis W. 2023. Effect of cow manure fertilizer on growth, polyphenol content, and antioxidant activity of purslane plants. International Journal of Chemical and Biochemical Sciences, 23(1): 43–54.

Ma J, Xin X, Cao Y, Zhao L, Zhang Z, Zhang D, Fu Z, Sun J. 2024. Root growth characteristics and antioxidant system of Suaeda salsa in response to the short-term nitrogen and phosphorus addition in the Yellow River Delta. Frontiers in Plant Science, 15:1-11. https://doi.org/10.3389/fpls.2024.1410036

Madani H, Escrich A, Hosseini B, Sanchez-Muñoz R, Khojasteh A, Palazon J. 2021. Biomolecule’s effect of polyploidy induction on natural metabolite production in medicinal plants. 11. https://doi.org/10.3390/biom

Mansoor S, Wani OA, Lone JK, Manhas S, Kour N, Alam P, Ahmad A, Ahmad P. 2022. Reactive oxygen species in plants: From source to sink. Antioxidants, 11(2): 1-14. MDPI. https://doi.org/10.3390/antiox11020225

Mardiyanto MB, Foresty RS, Arlysia V, Chorunissa ZFN, NugrohoGD, Yasa A, Naim DM, Setyawan AD. 2023. Plants as herbal medicine at Nguter Traditional Market, Sukoharjo, Central Java, Indonesia. Asian Journal of Ethnobiology, 6(1):65–74. https://doi.org/10.13057/asianjethnobiol/y060108

Masturi, Alighiri D, Edie SS, Hanisyifa U, Drastisianti A. 2021. Determination of total phenol and flavonoid contents and antioxidant activity from extract fraction of sappan wood (Caesalpinia sappan l.) by liquid-liquid extraction and vacuum liquid chromatography. Asian Journal of Chemistry, 33(8):1729–1735. https://doi.org/10.14233/ajchem.2021.23029

Mhamdi A, Van Breusegem F. 2018. Reactive oxygen species in plant development. Development (Cambridge), 145: 1-12. https://doi.org/10.1242/dev.164376

Miranda I, Sousa V, Ferreira J, Pereira H. 2017. Chemical characterization and extractives composition of heartwood and sapwood from Quercus faginea. PLoS ONE, 12(6). https://doi.org/10.1371/journal.pone.0179268

Mueller M, Weinmann D, Toegel S, Holzer W, Unger FM, Viernstein H. 2016. Compounds from Caesalpinia sappan with anti-inflammatory properties in macrophages and chondrocytes. Food and Function, 7(3):1671–1679. https://doi.org/10.1039/c5fo01256b

Muscolo A, Sidari M, Settineri G, Papalia T, Mallamaci C, Attinà E. 2019. Influence of soil properties on bioactive compounds and antioxidant capacity of Brassica rupestris Raf. Journal of Soil Science and Plant Nutrition, 19(4): 808–815. https://doi.org/10.1007/s42729-019-00080-5

Naik PM, Al-Khayri JM. 2016. Abiotic and biotic elicitors–role in secondary metabolites production through in vitro culture of medicinal plants. In Abiotic and Biotic Stress in Plants - Recent Advances and Future Perspectives. InTech, 10: 247-277. https://doi.org/10.5772/61442

Nava-Tapia DA, Cayetano-Salazar L, Herrera-Zúñiga LD, Bello-Martínez J, Mendoza-Catalán MA, Navarro-Tito N. 2022. Brazilin: Biological activities and therapeutic potential in chronic degenerative diseases and cancer. In Pharmacological Research, 175: 1-14. Academic Press. https://doi.org/10.1016/j.phrs.2021.106023

Ndhlala AR, Ngobeni GT, Mulaudzi R, Lebelo SL. 2025. Different temperature storage conditions and packaging types affects colour parameters, amino acid composition, microbial contamination, and key bioactive molecules of Moringa oleifera Lam. Powder. Molecules, 30(20). https://doi.org/10.3390/molecules30204048

Ngamwonglumlert L, Devahastin S, Chiewchan N, Raghavan GSV. 2020. Color and molecular structure alterations of brazilein extracted from Caesalpinia sappan L. under different pH and heating conditions. Scientific Reports, 10: 1-10. https://doi.org/10.1038/s41598-020-69189-3

Nirmal NP, Rajput MS, Prasad RGSV, Ahmad M. 2015. Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review. Asian Pacific Journal of Tropical Medicine, 8(6): 421–430. https://doi.org/10.1016/j.apjtm.2015.05.014

Niu Y, Wang S, Li C, Wang J, Liu Z, Kang W. 2020. Effective compounds from Caesalpinia sappan L. on the Tyrosinase in vitro and in vivo. Natural Product Communications, 15(4): 1–8. https://doi.org/10.1177/1934578X20920055

Nurulita U, Harahap ZA. 2025. 3rd Lawang Sewu International Symposium on Medical and Health Sciences. 1. Spinger Nature. Available at: https://books.google.co.id/books?hl=id&lr=&id=qo9qEQAAQBAJ&oi=fnd&pg=PA304&dq=sappanwood+seedlings&ots=d6Lg4hUMR5&sig=5w_XHz96DH8yqn42PMKGij1yYME&redir_esc=y#v=onepage&q=sappanwood%20seedlings&f=false

Pagare S, Bhatia M, Tripathi N, Pagare S, Bansal YK. 2015. Secondary metabolites of plants and their role: Overview. Current trends in biotechnology and pharmacy, 9(3): 293-304.

Pant P, Pandey S, Dall’Acqua S. 2021. The influence of environmental conditions on secondary metabolites in medicinal plants: A literature review. In Chemistry and Biodiversity, 18(11). John Wiley and Sons Inc. https://doi.org/10.1002/cbdv.202100345

Patel RM, Patel KH, Adhvaryu MR. 2024. Enhancement of secondary metabolite production in tinospora cordifolia suspension cultures using gibberellic acid elicitation: A Comprehensive analysis of alkaloids and phenols. International Journal of Innovative Science and Research Technology (IJISRT), 910–917. https://doi.org/10.38124/ijisrt/ijisrt24nov500

Patil M, Sharma S, Sridhar K, Anurag RK, Grover K, Dharni K, Mahajan S, Sharma M. 2024. Effect of postharvest treatments and storage temperature on the physiological, nutritional, and shelf-life of broccoli (Brassica oleracea) microgreens. Scientia Horticulturae, 327. https://doi.org/10.1016/J.SCIENTA.2023.112805

Purba T, Situmeang R, Rohman HF, Mahyati, Arsi, Firgiyanto R, Junaedi AS, Saadah TT, Junairiah, Herawati J, Suhastyo AA. 2021. Pemupukan dan Teknologi Pemupukan. In R. Watrianthos (Ed.), Yayasan Kita Menulis (1st ed.).

Putri EA, Rahmadhia SN, Septiyani R. 2024. Estimation of the shelf life of wedang uwuh ready to drink with blanching and non blanching treatments. Jurnal Al-Azhar Indonesia Seri Sains dan Teknologi, 9(1). https://doi.org/10.36722/sst.v9i1.2133

Rahayu YYS, Araki T, Rosleine D. 2020. Factors affecting the use of herbal medicines in the universal health coverage system in Indonesia. Journal of Ethnopharmacology, 260. https://doi.org/10.1016/j.jep.2020.112974

Rahimi A, Gitari H, Lyons G, Heydarzadeh S, Tuncturk M, Tuncturk R. 2023. Effects of vermicompost, compost and animal manure on vegetative growth, physiological and antioxidant activity characteristics of Thymus vulgaris L. under water stress. Yuzuncu Yil University Journal of Agricultural Sciences, 33(1): 40–53. https://doi.org/10.29133/yyutbd.1124458

Rajput MS, Nirmal NP, Nirmal SJ, Santivarangkna C. 2022. Bio-actives from Caesalpinia sappan L.: Recent advancements in phytochemistry and pharmacology. South African Journal of Botany, 151: 60–74. https://doi.org/10.1016/j.sajb.2021.11.021

Raptania CN, Zakia S, Fahira AI, Amalia R. 2024. Article review: Brazilin as potential anticancer agent. Frontiers in Pharmacology, 15: 1-9. Frontiers Media SA. https://doi.org/10.3389/fphar.2024.1355533

Rosniawaty S, Ariyanti M, Mubarok S, Sudirja R, Rachman AL, Septiani D, Hamis ZM. 2025a. Impact of elicitor applications and planting distances on growth and phytochemical properties of Sappanwood (Caesalpinia sappan L.). Research on Crops, 26(1): 132-137. https://doi.org/10.31830/2348-7542.2025.ROC-1152

Rosniawaty S, Bahjatien ID, Soleh MA, Ariyanti M, Sudirja R. 2024b. Potensi metil jasmonat dan asam salisilat sebagai elisitor dalam mempengaruhi pertumbuhan bibit tanaman secang (Caesalpinia sappan L.). Agroland, 31(1): 55–62.

Rosniawaty S, Prasasta FP, Ariyanti M, Anjarsari IRD, Soleh MA, Mubarok S, Sudirja R. 2024c. Effect of crop pattern and types of manure on the growth of Sappan wood (Caesalpinia Sappan L.) in Jatinangor, West Java, Indonesia. Research on Crops, 25(1): 122–127. https://doi.org/10.31830/2348-7542.2024.ROC-1042

Rosniawaty S, Anjarsari IRD, Sudirja R, Mubarok S, Fatmawati D. 2023d. Effect of growth regulators and organic matter on the growth of Sappan wood seedlings (Caesalpinia sappan L.). Research on Crops, 24(1): 198–209. https://doi.org/10.31830/2348-7542.2023.ROC-896

Rosniawaty S, Al-Adawiah AR, Mubarok S, Sudirja R, Ariyanti M. 2023e. Respons pertumbuhan akar bibit secang (Caesalpinia sappan L.) di dataran rendah terhadap sitokinin dan giberelin. Agrisaintifika, 7(1).

Rupngam T, Udomkun P, Boonupara T, Kaewlom P. 2025. Enhancing soil health, growth, and bioactive compound accumulation in sunflower sprouts using agricultural byproduct-based soil amendments. Agronomy, 15: 1-33. https://doi.org/10.3390/agronomy15051213

Sakti AS, Saputri FC, Mun’im A. 2019. Optimization of choline chloride-glycerol based natural deep eutectic solvent for extraction bioactive substances from Cinnamomum burmannii barks and Caesalpinia sappan heartwoods. Heliyon, 5: 1-9. https://doi.org/10.1016/j.heliyon.2019.e02915

Sanam SC, Marzvan S, Khiavi SJ, Rahimi M. 2020. Changes in growth, biochemical, and chemical characteristics and alteration of the antioxidant defense system in the leaves of tea clones (Camellia sinensis L.) under drought stress. Scientia Horticulturae, 265: 1-10. https://doi.org/10.1016/j.scienta.2020.109257

Sarwar M, Patra JK, Ali A, Maqbool M, Arshad MI. 2020. Effect of compost and NPK fertilizer on improving biochemical and antioxidant properties of Moringa oleifera. South African Journal of Botany, 129: 62–66. https://doi.org/10.1016/j.sajb.2019.01.009

Septiani D, Suryadi H, Mun’im A. 2022. Improving enzyme-assisted extraction of brazilin from Sappanwood (Caesalpinia Sappan L.) extract by fungal cellulase. Pharmacognosy Journal, 14(1): 21–28. https://doi.org/10.5530/pj.2022.14.4

Septiyani R, Wikandari R, Santoso U, Raharjo S. 2024. Brazilin content, color stability, and antioxidant activity of sappan wood (Caesalpinia Sappan L.) traditional drink by different blanching and drying methods. Trends in Sciences, 21(12). https://doi.org/10.48048/tis.2024.8535

Settharaksa S, Monton C, Charoenchai L. 2019. Optimization of Caesalpinia sappan L. heartwood extraction procedure to obtain the highest content of brazilin and greatest antibacterial activity. Journal of Integrative Medicine, 17(5): 351–358. https://doi.org/10.1016/j.joim.2019.05.003

Setyowati N, Masyhuri, Mulyo JH, Irham, Yudhistira B. 2023. The hidden treasure of wedang uwuh, an ethnic traditional drink from Java, Indonesia: Its benefits and innovations. International Journal of Gastronomy and Food Science, 31. https://doi.org/10.1016/j.ijgfs.2023.100688

Singh J, Mirza A, Singh S, Singh P. 2017a. Impact of phytohormons on physyio-chemical properties of tropical and subtropical fruits: A review. Plant Archives, 18(1): 12–18.

Singh R, Singh S, Parihar P, Mishra RK, Tripathi DK, Singh V., Chauhan DK, Prasad SM. 2016b. Reactive oxygen species (ROS): Beneficial companions of plants’ developmental processes. In Frontiers in Plant Science, 7: 1-19. Frontiers Media S.A. https://doi.org/10.3389/fpls.2016.01299

Srisaikham S, Rupitak Q. 2020. Growth of Caesalpinia sappan L. by using different growing media and evaluation of antioxidant activity of foliage. Science Technology and Engineering Journal (STEJ), 6(2): 50–61. https://stej.msu.ac.th/wp-content/uploads/2021/01/JOURNAL-STEJ6-2-0005-56-67.pdf

Tamburini D. 2019. Investigating Asian colourants in Chinese textiles from Dunhuang (7th-10th century AD) by high performance liquid chromatography tandem mass spectrometry – Towards the creation of a mass spectra database. Dyes and Pigments, 163: 454–474. https://doi.org/10.1016/j.dyepig.2018.12.025

Thanayutsiri T, Patrojanasophon P, Opanasopit P, Ngawhirunpat T, Laiwattanapaisal W, Rojanarata T. 2023. Rapid and efficient microwave-assisted extraction of Caesalpinia sappan Linn. heartwood and subsequent synthesis of gold nanoparticles. Green Processing and Synthesis, 12:1–9. https://doi.org/10.1515/gps-2022-8109

Thiyageshwari S, Gayathri P, Krishnamoorthy R, Anandham R, Paul D. 2018. Exploration of rice husk compost as an alternate organic manure to enhance the productivity of blackgram in typic haplustalf and typic rhodustalf. International Journal of Environmental Research and Public Health, 15: 1-14. https://doi.org/10.3390/ijerph15020358

Torun H, Novák O, Mikulík J, Pěnčík A, Strnad M, Ayaz FA. 2020. Timing-dependent effects of salicylic acid treatment on phytohormonal changes, ROS regulation, and antioxidant defense in salinized barley (Hordeum vulgare L.). Scientific Reports, 10(1): 1–17. https://doi.org/10.1038/s41598-020-70807-3

Tu WC, Ding LF, Peng LY, Song LD, Wu X-De, Zhao QS. 2022. Cassane diterpenoids from the seeds of Caesalpinia bonduc and their nitric oxide production and α-glucosidase inhibitory activities. Phytochemistry, 193: 1-11. https://doi.org/10.1016/j.phytochem.2021.112973

Twaij BM, Hasan MN. 2022. Bioactive secondary metabolites from plant sources: Types, synthesis, and their therapeutic uses. International Journal of Plant Biology, 13(1): 4–14. https://doi.org/10.3390/ijpb13010003

Uddin GM, Kim CY, Chung D, Kim KA, Jung SH. 2015. One-step isolation of sappanol and brazilin from Caesalpinia sappan and their effects on oxidative stress-induced retinal death. BMB Reports, 48(5) :289–294. https://doi.org/10.5483/BMBRep.2015.48.5.189

Utari FD, Sari DA, Kurniasari L, Kumoro AC, Djaeni M, Hii CL. 2023. The enhancement of sappanwood extract drying with foaming agent under different temperature. AIMS Agriculture and Food, 8(1): 214–235. https://doi.org/10.3934/AGRFOOD.2023012

Vij T, Anil PP, Shams R, Dash KK, Kalsi R, Pandey VK, Harsányi E, Kovács B, Shaikh AM. 2023. A comprehensive review on bioactive compounds found in Caesalpinia sappan. Molecules, 28: 1-22. Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/molecules28176247

Wang J, Song L, Gong X, Xu J, Li M. 2020a. Functions of jasmonic acid in plant regulation and response to abiotic stress. International Journal of Molecular Sciences, 21: 1-17. https://doi.org/10.3390/ijms21041446

Wang P, Liu WC, Han C, Wang S, Bai MY, Song CP. 2024b. Reactive oxygen species: Multidimensional regulators of plant adaptation to abiotic stress and development. In Journal of Integrative Plant Biology, 66(3): 330-367. John Wiley and Sons Inc. https://doi.org/10.1111/jipb.13601

Wani SH, Kumar V, ShriramV, Sah SK. 2016. Phytohormones and their metabolic engineering for abiotic stress tolerance in crop plants. Crop Journal, 4(3): 162–176. https://doi.org/10.1016/j.cj.2016.01.010

Waszczak C, Carmody M, Kangasjärvi J. 2018. Reactive oxygen species in plant signaling. Annual Review of Plant Biology, 1: 209–236. https://doi.org/10.1146/annurev-arplant-042817

Wudtiwai B, Kodchakorn K, Shwe TH, Pothacharoen P, Phitak T, Suninthaboonrana R, Kongtawelert P. 2023. Brazilein inhibits epithelial-mesenchymal transition (EMT) and programmed death ligand 1 (PD-L1) expression in breast cancer cells. International Immunopharmacology, 118: 1-12. https://doi.org/10.1016/j.intimp.2023.109988

Wyk ASV, Prinsloo G. 2020. Health, safety and quality concerns of plant-based traditional medicines and herbal remedies. In South African Journal of Botany, 133: 54-62. Elsevier B.V. https://doi.org/10.1016/j.sajb.2020.06.031

Xuan Q, Zhou JF, Jiang F, Zhang W, Wei A, Zhang W, Zhang Q, Shen H, Li H, Chen C, Wang P. 2022. Sappanwood-derived polyphenolic antidote of amyloidal toxins achieved detoxification via inhibition/reversion of amyloidal fibrillation. International Journal of Biological Macromolecules, 214: 446–458. https://doi.org/10.1016/j.ijbiomac.2022.06.141

Yan X, Xu L, Qi C, Chang Y, Zhang J, Li N, Shi B, Guan B, Hu S, Huang C, Wang H, Chen Y, Xu X, Lu J, Xu G, Chen C, Li S, Chen Y. 2025. Brazilin alleviates acute lung injury via inhibition of ferroptosis through the SIRT3/GPX4 pathway. Apoptosis, 30: 768–783. https://doi.org/10.1007/S10495-024-02058-W/METRICS

Yang L, Wen KS, Ruan X, Zhao YX, Wei F, Wang Q. 2018. Response of plant secondary metabolites to environmental factors. In Molecules, 23: 1-26. MDPI AG. https://doi.org/10.3390/molecules23040762

Zhang J, Shoaib N, Lin K, Mughal N, Wu X, Sun X, Zhang L, Pan K. 2024. Boosting cadmium tolerance in Phoebe zhennan: The synergistic effects of exogenous nitrogen and phosphorus treatments promoting antioxidant defense and root development. Frontiers in Plant Science, 15: 1-17. https://doi.org/10.3389/fpls.2024.1340287

Zhao B, Liu Q, Wang B, Yuan F. 2021. Roles of phytohormones and their signaling pathways in leaf development and stress responses. Journal of Agricultural and Food Chemistry, 69(12): 3566–3584. https://doi.org/10.1021/acs.jafc.0c0790

Zhu NL, Sun ZH, Hu MG, Wu TY, Yuan JQ, Wu HF, Tian Y, Li PF, Yang JS, Ma GX, Xu XD. 2017. New cassane diterpenoids from Caesalpinia sappan and their antiplasmodial activity. Molecules, 22(10). https://doi.org/10.3390/molecules22101751




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