Pola konsumsi makanan dan minuman pada penderita oral squamous cell carcinoma: Studi cross-sectional

Muhammad Fadhlan Izzul Haq, Asty Samiaty Setiawan, Jamas Ari Anggraini

Abstract


ABSTRAK

Pendahuluan: Oral squamous cell carcinoma (OSCC) merupakan salah satu kanker yang paling umum terjadi di dunia. Perubahan pola konsumsi makanan dan gaya hidup dapat meningkatkan risiko kanker. Studi mengenai gambaran pola konsumsi makanan dan minuman pada penyakit keganasan pada rongga mulut di Indonesia masih belum memadai. Penelitian ini bertujuan untuk mengetahui gambaran pola konsumsi makanan dan minuman pada penderita keganasan rongga mulut. Metode: Jenis penelitian yang digunakan adalah penelitian deskriptif observasional dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah pasien penderita OSCC di Poli Bedah Mulut Rumah Sakit Hasan Sadikin Kota Bandung selama periode September sampai dengan November 2024. Teknik pengambilan sampel menggunakan teknik non probability sampling yaitu accidental sampling. Pengambilan data dilakukan menggunakan Food Frequency Questionnaire (FFQ) Hasil: Bahan makanan dan minuman perharinya yang paling sering dikonsumsi oleh penderita OSCC berdasarkan kelompok makanannya adalah nasi, telur, bakso, ikan asin, susu, mentimun, jeruk, pisang, penyedap rasa “M” serta kopi non instan. Simpulan: Pola konsumsi makanan dan minuman pada penderita OSCC memiliki kecenderungan mengkonsumsi makanan atau minuman yang bersifat karsinogenik lebih banyak dibandingkan makanan atau minuman yang memiliki khasiat kemopreventif.

KATA KUNCI: Pola makanan dan minuman, oral squamous cell carcinoma, keganasan rongga mulut, risiko kanker, FFQ

Dietary pattern of food and beverage consumption patterns in patients oral squamous cell carcinoma: Study cross-sectional 

ABSTRACT

Introduction: Oral squamous cell carcinoma (OSCC) is one of the most common cancers in the world. Changes in food consumption patterns and lifestyle can increase the risk of cancer. Studies on the description of food and beverage consumption patterns in malignancies of the oral cavity in Indonesia are still inadequate. This study aims to determine the description of food and beverage consumption patterns in patients with oral malignancies. Methods: The type of research used was descriptive observational research with a cross-sectional approach. The population in this study were patients with OSCC in the Oral Surgery Poly of Hasan Sadikin Hospital, Bandung City during the period September to November 2024. The sampling technique used a non-probability sampling technique, namely accidental sampling. Data collection was carried out using the Food Frequency Questionnaire (FFQ). Results: The results showed that the most frequently consumed food and beverages per day by OSCC patients based on food groups were rice, eggs, meatballs, salted fish, milk, cucumber, banana, flavoring “M” and coffee. Conclusions: Dietary pattern of food and beverage consumption patterns in OSCC patients, the majority have a high level of food consumption of carcinogenic foods. Meanwhile, the level of consumption of foods with chemopreventive properties is relatively low.

KEY WORDS: Food and beverage patterns, oral squamous cell carcinoma, oral malignancies, cancer risk, FFQ


Keywords


Pola makanan dan minuman, oral squamous cell carcinoma, keganasan rongga mulut, risiko kanker, FFQ, Food and beverage patterns, oral squamous cell carcinoma, oral malignancies, cancer risk, FFQ

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References


DAFTAR PUSTAKA

WHO. Oral health [Internet]. World Health Organization. 2024 [cited 2025 Jan 7]. Available from: https://www.who.int/news-room/fact-sheets/detail/oral-health

Huang GZ, Wu QQ, Zheng ZN, Shao TR, Lv XZ. Identification of candidate biomarkers and analysis of prognostic values in oral squamous cell carcinoma. Front Oncol. 2019;9(OCT). https://doi.org/10.3389/fonc.2019.01054

Montero PH, Patel SG. Cancer of the Oral Cavity. Vol. 24, Surgical Oncology Clinics of North America. W.B. Saunders; 2015. p. 491–508. https://doi.org/10.1016/j.soc.2015.03.006

Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, et al. Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci . 2023;15(1):44. https://doi.org/10.1038/s41368-023-00249-w

Capote-Moreno A, Brabyn P, Muñoz-Guerra MF, Sastre-Pérez J, Escorial-Hernandez V, Rodríguez-Campo FJ, et al. Oral squamous cell carcinoma: epidemiological study and risk factor assessment based on a 39-year series. Int J Oral Maxillofac Surg [Internet]. 2020;49(12):1525–34. https://doi.org/10.1016/j.ijom.2020.03.009

WHO. The Global Cancer Observatory [Internet]. International Agency for Research on Cancer. 2022 [cited 2025 Jan 1]. Available from: https://gco.iarc.fr/today/en/dataviz/pie?mode=population&group_populations=0&cancers=1&types=1

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.1002/cac2.12009

Ren Z, Hu C, He H, Li Y, Lyu J. Global and regional burdens of oral cancer from 1990 to 2017: Results from the global burden of disease study. Cancer Commun. 2020;40(2–3):81–92. Available from: https://onlinelibrary.wiley.com/doi/10.1002/cac2.12009

Cheong SC, Vatanasapt P, Yi-Hsin Y, Zain RB, Kerr AR, Johnson NW. Oral cancer in South East Asia. Translational Research in Oral Oncology. 2017 Jan;2:2057178X1770292. https://doi.org/10.1177/2057178X17702921

Salarić I, Karmelić I, Lovrić J, Baždarić K, Rožman M, Čvrljević I, et al. Salivary melatonin in oral squamous cell carcinoma patients. Sci Rep. 2021;11(1). https://doi.org/10.1038/s41598-021-92649-3

Akinkugbe AA, Garcia DT, Brickhouse TH, Mosavel M. Lifestyle risk factor related disparities in oral cancer examination in the U.S: A population-based cross-sectional study. BMC Public Health. 2020;20(1). https://doi.org/10.1186/s12889-020-8247-2

Riskayanti NP, Riyanto D, Winias S. Manajemen multidisiplin Oral Squamous Cell Carcinoma (OSCC): laporan kasus. Intisari Sains Medis. 2021;12(2):621. https://doi.org/10.15562/ism.v12i2.1076

Athukorala IA, Tilakaratne WM, Jayasinghe RD. Areca Nut Chewing: Initiation, Addiction, and Harmful Effects Emphasizing the Barriers and Importance of Cessation. J Addict. 2021;2021:1–9. https://doi.org/10.1155/2021/9967097

Ali J, Sabiha B, Jan HU, Haider SA, Khan AA, Ali SS. Genetic etiology of oral cancer. Vol. 70, Oral Oncology. Elsevier Ltd; 2017. p. 23–8. https://doi.org/10.1016/j.oraloncology.2017.05.004

Fantozzi PJ, Bavarian R, Tamayo I, Bind MA, Woo S Bin, Villa A. The role of family history of Cancer in Oral Cavity Cancer. Head Face Med. 2021;17(1). https://doi.org/10.1186/s13005-021-00298-8

Deshmukh V, Shekar K. Oral Squamous Cell Carcinoma: Diagnosis and Treatment Planning. In: Oral and Maxillofacial Surgery for the Clinician. Springer Nature Singapore; 2021. p. 1853–67. https://doi.org/10.1007/978-981-15-1346-6_81

Gayathri C, Sivaramakrishnan M, Suganya R, Santhadevy A, Vezhavendhan N. Pathogenesis of oral squamous cell carcinoma- An update. Int Dent J Student’s Res. 2020;7(4):84–6. https://doi.org/10.18231/j.idjsr.2019.022

Rodríguez-Molinero J, Migueláñez-Medrán BDC, Puente-Gutiérrez C, Delgado-Somolinos E, Martín Carreras-Presas C, Fernández-Farhall J, López-Sánchez AF. Association between Oral Cancer and Diet: An Update. Nutrients. 2021;13(4):1299 https://doi.org/10.3390/nu13041299

Castro-Quezada I, Román-Viñas B, Serra-Majem L. The Mediterranean diet and nutritional adequacy: a review. Nutrients. 2015;6(1):231-48. https://doi.org/10.1016/B978-0-12-407849-9.00002-6

Cespedes EM, Hu FB. Dietary patterns: From nutritional epidemiologic analysis to national guidelines. Vol. 101, American Journal of Clinical Nutrition. American Society for Nutrition; 2015. p. 899–900. https://doi.org/10.3945/ajcn.115.110213

de Oliveira Bezerra KF, de Oliveira DWD, Menezes-Silva R, Granville-Garcia F, Alves PM, Nonaka CFW, et al. Diet and squamous cell carcinoma of the oral cavity and pharynx: A case-control study. Pesqui Bras Odontopediatria Clin Integr. 2017 Jan 1;17(1). . https://doi.org/10.4034/PBOCI.2017.171.31

Ksouri R. Food components and diet habits: Chief factors of cancer development. Vol. 3, Food Quality and Safety. Oxford University Press; 2019. p. 227–31. https://doi.org/10.1093/fqsafe/fyz021

Gustavo Secchi D, Aballay LR, Galíndez MF, Piccini D, Lanfranchi H, Brunotto MN. Red meat, micronutrients and oral squamous cell carcinoma of argentine adult patients. Nutr Hosp. 2015 Aug 28;32(3):1214–21.

Reis MG, Lopes LC, Sanches ABAMDA, Guimarães NS, Martins-Chaves RR. Diet and Oral Squamous Cell Carcinoma: A Scoping Review. Int J Environ Res Public Health. 2024 Sep 10;21(9):1199. https://doi.org/10.3390/ijerph21091199

Nurmalina R, Hafizah D, Budiman Hakim D. Analysing Food Consumption in Indonesia. International Journal of Progressive Sciences and Technologies (IJPSAT) [Internet]. 2020;20(2):340–7.

Maulina T, et al. The incidence of oral squamous cell carcinoma (OSCC) and its relationship with orofacial pain in oral cancer patients in West Java Province, Indonesia. J Oral Maxillofac Surg Med Pathol. 2016; 9(1) http://dx.doi.org/10.1016/j.ajoms.2016.09.001

Sijaruddin, Surmita, Astuti T. Survey Konsumsi Pangan. Kementrian Kesehatan Republik Indonesia; 2018. Pp.1-87

Handayanti SP, Nasoetion A, Sukandar D. Konversi Satuan Ukuran Rumah Tangga ke Dalam Satuan Berat (Gram) pada Beberapa Jenis Pangan Sumber Protein. J Gizi dan Pangan, Maret 2008 3(1):49-60. https://doi.org/10.25182/jgp.2008.3.1.49-60

Al-Rahmad AH, Rusmawar D, Fadjri K, Massyudi. Standar Konversi Ukuran Rumah Tangga (URT) ke dalam Nilai Zat Gizi di pedesaan Kecamatan Simpang Tiga Aceh Besar. SAGO: Gizi dan Kesehatan 2019;1(1):101-102. https://doi.org/10.30867/gikes.v1i1.305

Wibowo IS, Priyanto W, Hardianto A. Karateristik Karsinoma Sel Skuamosa Rongga Mulut di RSUP DR. Hasan Sadikin Bandung Periode Januari-Desember 2019. Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya. 2022 Feb 17;9(1):97–102. https://doi.org/10.32539/JKK.V9I1.15119

Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024 Jan;74(1):12–49. https://doi.org/10.3322/caac.21820

Sankaranarayanan R, Ramadas K, Amarasinghe H, et al. Oral Cancer: Prevention, Early Detection, and Treatment. In: Gelband H, Jha P, Sankaranarayanan R, et al., editors. Cancer: Disease Control Priorities, 3rdEd. (Volume 3). Washington (DC): The International Bank for Reconstruction and Development / The World Bank; 2015 Nov 1. Chapter 5. Available from: https://www.ncbi.nlm.nih.gov/books/NBK343649/ doi: 10.1596/978-1-4648-0349-9_ch5

Pratiwi Y. Distribusi Kanker Mulut di Rumah Sakit Umum Pusat dr. M. Djamil Padang. Universitas Baiturrahmah; 2024.

Lin NC, Hsu JT, Tsai KY. Difference between female and male patients with oral squamous cell carcinoma: A single-center retrospective study in Taiwan. Int J Environ Res Public Health. 2020;17(11):1–8. https://doi.org/10.3390/ijerph17113978

BPS. Upah Minimum Regional/Provinsi (UMR/UMP) Perbulan (dalam rupiah) [Internet]. [cited 2024 Dec 12]. Available from: http://www.bps.go.id

Lubis WH, Suppaya SR. Hubungan Status Ekonomi dan Pengetahuan Masyarakat terhadap Kanker Rongga Mulut di Kotamadya Medan 2014. Insisiva Dental Journal. 2016;5(1):33-9.

Odell EW. Cawson’s Essentials of Oral Pathology and Oral Medicine. 9th Ed. Elsevier; 2017.

Sari EF, Johnson NW, McCullough MJ, Cirillo N. Prevalence and risk factors of oral potentially malignant disorders in Indonesia: a cross-sectional study undertaken in 5 provinces. Sci Rep. 2024 Mar 4;14(1):5232. doi: 10.1038/s41598-024-54410-4. https://doi.org/10.1038/s41598-024-54410-4

Liu H, Yu Z, Xu Z, Liu T, Liu W. A scientometric study of tobacco and alcohol use as risk factors for oral cavity health. J Dent Sci. 2023 Oct 1;18(4):1883–8. https://doi.org/10.1016/j.jds.2023.05.016

Sumerti NN. Merokok dan Efeknya Terhadap Kesehatan Gigi dan Rongga Mulut. Vol. 4, Dental Health Journal. Denpasar; 2016.

Jiang X, Wu J, Wang J, Huang R. Tobacco and oral squamous cell carcinoma: A review of carcinogenic pathways. Tob Induc Dis. 2019 Apr 12;17:29. https://doi.org/10.18332/tid/105844

Dewi YDP, Purwidiani N. Studi Pola Konsumsi Makanan Pokok pada Penduduk Desa Pangendingan Kecamatan Galis Kabupaten Pamekasan Madura. e-Jornal Boga, 2015 4(3): 108-121.

Zhang R, Zhang X, Wu K, Wu H, Sun Q, Hu FB, Han J, Willett WC, Giovannucci EL. Rice consumption and cancer incidence in US men and women. Int J Cancer. 2016 Feb 1;138(3):555-64. https://doi.org/10.1002/ijc.29704

Sanchez, T.R., Klu, Y.A.K., Genkinger, J.M. et al. Association between rice consumption and risk of cancer incidence in the California Teachers Study. Cancer Causes Control.2020; 31, 1129–40. https://doi.org/10.1007/s10552-020-01350-9.

Hamied, Marwa & Mohammad, Salwa. (2019). Food and Risk of Oral Cancer (Review). Tikrit Journal for Dental Sciences. 7. 45-54. 10.25130/tjds.7.2.1. https://doi.org/10.25130/tjds.7.2.1

Lu Liu, Ting Sun, Hongdie Liu, Jingyi Li, Li Tian. Carbohydrate quality vs quantity on cancer Risk: Perspective of microbiome mechanisms, Journal of Functional Foods, 2024,1 118, 06246, ,https://doi.org/10.1016/j.jff.2024.106246.

Ma H, Qi X. Red Meat Consumption and Cancer Risk: A Systematic Analysis of Global Data. Foods. 2023 Nov 17;12(22):4164. https://doi.org/10.3390/foods12224164

Momal U,et.al. Recent Perspectives on Meat Consumption andCancer Proliferation. Journal of Food Processing and Preservation.2025; 1 : 6567543. https://doi.org/10.1155/jfpp/6567543

Kliemann N, Al Nahas A, Vamos EP, Touvier M, Kesse-Guyot E, Gunter MJ, et al. Ultra-processed foods and cancer risk: from global food systems to individual exposures and mechanisms. British J Cancer. 2022; 127:14-20. https://doi.org/10.1038/s41416-022-01749-y

Monteiro CA, Cannon G, Lawrence M, Laura Da Costa Louzada M, Machado PP. Ultra-processed foods, diet quality, and health using the NOVA classification system Prepared by [Internet]. 2019. Available from: http://www.wipo.int/amc/en/mediation/rules

Chang K, Gunter MJ, Rauber F, Levy RB, Huybrechts I, Kliemann N, et al. Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK Biobank. EClinicalMedicine. 2023 Feb 1;56. https://doi.org/10.1016/j.eclinm.2023.101840

Morales-Berstein F, Biessy C, Viallon V, Goncalves-Soares A, Casagrande C, Hémon B, et al. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis. Eur J Nutr. 2024 Mar 1;63(2):377–96. https://doi.org/10.1007/s00394-023-03270-1

Kliemann N, Rauber F, Bertazzi Levy R, Viallon V, Vamos EP, Cordova R, et al. Food processing and cancer risk in Europe: results from the prospective EPIC cohort study. Lancet Planet Health. 2023 Mar 1;7(3):e219–32. https://doi.org/10.1016/S2542-5196(23)00021-9

Adilah F, Anggraini JA, Widyaputra S. The Effect of Salted Food on the Risk of Oral Cancer: A Systematic Review. Mal J Med Health Sci 20(SUPP12) 2024:114-123.

Sitepu SM, Hutagalung SB, Simanulang F. Hubungan Kebiasaan Konsumsi Ikan Asin dengan Terjadinya Karsinoma Nasofaring dan Non Karsinoma Nasofaring di RSU Vina Estetica Tahun 2022 - 2023. eJournal Methodis. 2023.

Food and Drug Administration. Safety of Monosodium Glutamate (MSG) and Aspartame as Food Additives. FDA Advisory No:2013-058.

El Imam H, abd El Salam N. Evaluation of the effect of monosodium glutamate administration on buccal mucosa of adult male albino rats. (histological and immuno-histochemical study). Egypt Dent J. 2019;65(3):2233–40.

Shredah M. Molecular study to the effect of monosodium glutamate on rat gingiva. Tanta Dent J. 2017;14(3):155. https://doi.org/10.4103/tdj.tdj_21_17

Mohammed SS. Monosodium glutamate induced genotoxicity in rat palatal mucosa. Tanta Dent J. 2017;14(3):112. https://doi.org/10.4103/tdj.tdj_20_17

Suwandi SNI, Anggraini JA, Widyaputra S. The effect of monosodium glutamate on the risk of oral cancer: a systematic review. Vol. 12, Bali Medical Journal. Sanglah General Hospital; 2023. p. 2500–12. https://doi.org/10.15562/bmj.v12i3.4645

Yuan J, Li W, Sun W, Deng S. Milk and dairy products consumption and the risk of oral or oropharyngeal cancer: a meta-analysis. Biosci Rep. 2019;39(12):BSR20193526. https://doi.org/10.1042/BSR20193526

Sari SDP. Pentingnya Konsumsi Sayur dan Buah [Internet]. Kemenkes Direktorat Jendral Pelayanan Kesehatan. 2023 [cited 2024 Dec 6]. https://doi.org/10.24167/patria.v6i1.10498

Dan Prihatini H, Pusat S, Dan P, Upaya P, Masyarakat K, Percetakan J. Gambaran Konsumsi Sayur dan Buah Penduduk Indonesia dalam Konteks Gizi Seimbang: Analisis Lanjut Survei Konsumsi Makanan Individu (SKMI) 2014. 2016. https://doi.org/10.36457/gizindo.v39i1.205

Alzate-Yepes T, Pérez-Palacio L, Martínez E, Osorio M. Mechanisms of Action of Fruit and Vegetable Phytochemicals in Colorectal Cancer Prevention. MDPI Molecules. 2023; 28. https://doi.org/10.3390/molecules28114322

Pauwels EKJ, Volterrani D. Coffee Consumption and Cancer Risk: An Assessment of the Health Implications Based on Recent Knowledge. Med Princ Pract. 2021;30(5):401-411. https://doi.org/10.1159/000516067

Kunutsor SK, Lehoczki A, Laukkanen JA. Coffee consumption, cancer, and healthy aging: epidemiological evidence and underlying mechanisms. Geroscience. 2025;47(2):1517-1555. https://doi.org/10.1007/s11357-024-01332-8




DOI: https://doi.org/10.24198/pjdrs.v9i2.60756

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