Potensi gel Stichopus hermanii dan Hyperbaric Oxygen Therapy untuk mempercepat perawatan ortodonti  Potential of Stichopus hermanii gel and Hyperbaric Oxygen Therapy in accelerating orthodontic treatment

I Ketut Ika Sandana; Jessica Velisia; Alexander Yunior; Arya Brahmanta; Noengki Prameswari

doi:10.24198/jkg.v29i3.15951

Potensi gel Stichopus hermanii dan Hyperbaric Oxygen Therapy untuk mempercepat perawatan ortodonti
Potential of Stichopus hermanii gel and Hyperbaric Oxygen Therapy in accelerating orthodontic treatment

I Ketut Ika Sandana, Jessica Velisia, Alexander Yunior, Arya Brahmanta, Noengki Prameswari

Abstract

Pendahuluan: Perawatan ortodonti memerlukan inovasi untuk mempercepat waktu perawatan. Perawatan ortodonti menyebabkan adanya daerah tekanan dan tarikan yang dipengaruhi oleh ekspresi Receptor Activator of Nuclear Factor Kappa-b (RANK) pada daerah tekanan, yang merangsang osteoklas dan ekspresi osteoprotegerin pada daerah tarikan yang merangsang osteoblast. Stichopus hermanii mempunyai efek pada proses penyembuhan, Hyperbaric Oxygen Therapy (HBOT) memberikan efek remodelling. Studi pustaka ini bertujuan untuk mengungkapkan mekanisme potensi gel Stichopus hermanii dan Hyperbaric Oxygen Therapy (HBOT) dalam mempercepat proses pergerakan gigi pada perawatan ortodonti sebagai alternatif terapi. Studi Pustaka: Inovasi untuk mempercepat perawatan ortodonti dilakukan pada daerah tekanan dan tarikan. Pemberian gel Stichopus hermanii secara lokal dapat meningkatkan level osteoprotegerin yang menghambat ikatan antara Receptor Activator of Nuclear Factor Kappa-b Ligand (RANK-L) dan Receptor Activator of Nuclear Factor Kappa-b (RANK), sehingga menghambat aktivasi osteoklas dan mengaktivasi aposisi tulang. Hyperbaric Oxygen Therapy menstimulasi ekspresi RANK pada daerah tekanan membantu mempercepat proses resorpsi. Kombinasi gel Stichopus hermanii dan Hyperbaric Oxygen Therapy menyebabkan pergerakan gigi meningkat melalui proses remodelling. Simpulan: Inovasi kombinasi terapi gel Stichopus hermanii dan Hyperbaric Oxygen Therapy dapat meningkatkan pergerakan gigi pada perawatan ortodonti.

Kata kunci: Pergerakan gigi ortodonti, Stichopus hermanii, Hyperbaric Oxygen Therapy, osteoprotegerin, RANK-L, RANK.

ABSTRACT

Introduction: Orthodontic treatment requires innovation to accelerate the treatment time — orthodontic treatment is resulting in pressure and pull area that is affected by the expression of the Receptor Activator of Nuclear Factor Kappa b (RANK) in the pressure region, which stimulates osteoclasts and expression of osteoprotegerin in the pulling region which stimulates the osteoblast. Stichopus hermanii affects the healing process, Hyperbaric Oxygen Therapy (HBOT) provides a remodelling effect. This literature study was aimed to reveal the potential mechanism of Stichopus hermanii and Hyperbaric Oxygen Therapy (HBOT) in accelerating the tooth movement process in orthodontic treatment as an alternative therapy. Literature Review: Innovations to accelerate orthodontic treatment were performed in the pressure and pull area. Administration of Stichopus hermanii gel could increase the level of osteoprotegerin which inhibits the bond between Receptor Activator of Nuclear Factor Kappa-b Ligand (RANK-L) and Receptor Activator of Nuclear Factor Kappa-b (RANK), thus inhibiting osteoclast activation and activating bone apposition. Hyperbaric Oxygen Therapy (HBOT) stimulates RANK expression in the pressure area to help accelerate the resorption process. Combinations of Stichopus hermanii gel and HBOT cause tooth movement to increase through the remodelling process. Conclusion: An innovative combination of Stichopus hermanii gel and Hyperbaric Oxygen Therapy (HBOT) was able to improve the tooth movement in orthodontic treatment.

Keywords: Orthodontic tooth movement, Stichopus hermanii gel, Hyperbaric Oxygen Therapy, osteoprotegerin, RANK-L, RANK.

Keywords

Pergerakan gigi ortodonti, Stichopus hermanii, hyperbaric, Hyperbaric Oxygen Therapy, osteoprotegerin, RANK-L, RANK, orthodontic tooth movement, Stichopus hermanii gel, Hyperbaric Oxygen Therapy, osteoprotegerin, RANK-L, RANK.

Full Text:

PDF

References

Laguhi VA, Anindita PS, Gunawan PN. Gambaran maloklusi dengan menggunakan HMAR pada pasien di rumah sakit gigi dan mulut Universitas Sam Ratulangi Manado. Jurnal e-Gigi (eG) 2014;2(2);1-7.

Wijayanti JK, Krisnawati, Ismah N. Gambaran maloklusi dan kebutuhan perawatan ortodonti pada anak usia 9-11 Tahun (Studi Pendahuluan di SD At-Taufiq, Cempaka Putih, Jakarta). Jurnal PDGI 2014;63(1):25-9.

Ardhana W. Ortodonsia III Perawatan ortodonti. Bagian Ortodonsia FKG UGM 2008. H. 6.

Nalcaci R, Demirer S, Ozturk F, Altan BA, Sokucu O, Bostanci V. The relationship of orthodontic treatment need with periodontal status, dental caries, and sociodemographic factor. The Scientific Wordl Journal 2012. H. 1-6.

Rahardjo P. Ortodonti dasar. Surabaya: Airlangga University Press. 2012. H. 2-5.

Sakinah N, Wibowo D, Helmi ZN. Peningkatan lebar lengkung gigi rahang atas melalui perawatan ortodonti menggunakan sekrup ekspansi. Dentino Jurnal Kedokteran Gigi 2016;1(1):83-7.

Alawiyah T, Sianita PP. Retensi dalam perawatan ortodonti. JITEKGI, 2012;9(2):29-35.

Alansari S, Sangsuwon C, Vongthongleur T, Kwal R, Teo MC, Lee YB dkk. Biological principle behind accelerated tooth movement. Seminars in Orthodontics 2015;21(3):151-61.

Henneman S, Hoff JWVD, Maltha JC. Mechanobiology of Tooth Movement. Europ J Orthod 2008;30:299-306.

Buschang PH, Campbell PM, Ruso S. Accelerating Tooth Movement With Corticotomies: Is it Possible And Desirable. Seminars In Orthodontics 2012;18(4):286-94.

Ge MK, He WL, Chen J, Wen C, Yin X, Hu ZA dkk. Efficacy of low level laser therapy for accelerating tooth movement during orthodontic treatment: A systematic review and meta-analysis. Lasers in Medical Science 2015;30(5):1609-18.

Rahardjo C, Prameswari N, Rahardjo P. Pengaruh gel teripang emas terhadap jumlah fibroblas di daerah tarikan pada relaps gigi setelah perawatan ortodonti. Dent J Kedok Gig 2014;8(1):26-33.

Ardhana W. Materi kuliah ortodonsia I prosedur pemeriksaan ortodontik. Yogyakarta: Universitas Gadjah Mada 2009. H. 3.

Ardhana W. Materi kuliah ortodonsia II biomekanika ortodonti. Yogyakarta: Universitas Gadjah Mada 2010. H. 1-7.

Joelijanto R. Factor That affect the duration of orthodontic treatment. The Second International Joint Symposium on Oral and Dental Sciences 2012. H. 228-32.

Iskandar P, Ismaniati NA. Peran prostaglandin pada pergerakan gigi ortodonti. Dentofacial 2010;9(2):91-100.

Kusumadewy W. Perbandingan kadar interleukin 1β (1L-1β) dalam cairan krevikular gingiva anterior mandibular pasien pada tahap awal perawatan ortodonsia menggunakan Braket self-ligating pasif dengan braket konvensional pre-adjusted MBT. Tesis. Jakarta: Universitas Indonesia 2012. H. 33.

Gill. The Effect of Orthodontic Therapy on Periodontal Health: A Review of the Literature. International Journal of Dentistry 2014(4):585048 May 2014 with 251 Reads. DOI: 10.1155/2014/585048

Krishnan V, Davidovitch Z. Cellular, molecular and tissue-level reactions to orthodontic force. Am J Orthod Dentofac Orthoped 2006;129(4):469.e1–469.e32.

Balajhi SI, Iyyer BS. Biology in tooth movement. In: Orthodontic-the art and science. 3th ed. New Delhi: Arya (MEDI) Publishing House 2006:94-181.

Cobourne MT, DiBiase AT. Orthodontic tooth movement. In: Handbook of orthodontics. Edinburg: Mosby Elsevier 2009. h. 12-107.

Singh G. Textbook of orthodontic 3rd ed. New Delhi: Jaypee Brothers Medical Publisher (P) Ltd 2015. H. 227-8.

Feller L, Khammissa RAG, Schechter I, Thomadakis G, Fourie J, Lemmer J. Biological events in periodontal ligament and alveolar bone associated with application of orthodontic forces. The Scientiﬁc World Journal 2015;2015:1-7.

Brahmanta A, Prameswari N. Fisiologi resorpsi tulang pada pergerakan gigi ortodontik. DENTA Jurnal Kedokteran Gigi 2009;4(1):5-6.

Ariffin SHZ, Yamamoto Z, Abidin IZZ, Wahab RMAW, Ariffin ZZ. Cellular and molecular changes in orthodontic tooth movement. The Scientific World Journal 2011;11:1788-803.

Kajarabille N, Díaz-Castro J, Hijano S, López-Frías M, López-Aliaga I, Ochoa JJ. A new insight to bone turnover: Role of -3 Polyunsaturated Fatty Acids. The Scientific World Journal 2013;2013:1-16.

Kitaura H, Kimura K, Ishida M, Sugisawa H, Kohara H, Yoshimatsu M, Yamamoto TT. Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane. The Scientific World Journal 2014. h.1-7.

Cochran DL. Inflammation and bone loss in periodontal disease. J Periodontal 2008;79:1569-76.

Boyce BF, Xing L. Biology of RANK, RANKL, and Osteoprotegerin. Biomed Central Ltd 2007. h. 9.

Parisihni K. Mekanisme molekuler ekstrak etanol teripang (stichopus hermanii) sebagai imunomodulator pada periodontitis kronis yang diinduksi porphyromonas gingivalis. Disertasi, Universitas Airlangga 2015.

Bordbar S, Anwar F, Sari N. High-value components and bioactives from sea cucumber for functional foods-a review. Marine Drugs 2011;9(10):1761-805.

Tehranifard A, Oryan S, Vosoghi G. Introducing a holothorian sea cucumber species stichopus hermanii from kish island in the persian gulf in Iran. Inter Conference on Environment and Industrial Inovation. IPCBEE 2011;12:138-43.

Trihapsari E. Faktor – faktor yang berhubungan dengan densitas mineral tulang wanita ≥ 45 Tahun di Departemen Pendidikan Nasional, Jakarta Pusat Tahun 2009. Skripsi. Universitas Indonesia 2009.

Mu J, Krafft PR, Zhang JH. Hyperbaric Oxygen Therapy Promotes Neurogenesis: Where Do We Stand?. Medical Gas Research 2011;1(14). Tersedia: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231808/

Braswel C, Crowe DT. Hyperbaric Oxygen Therapy. Compendium: Continuing Education for Veterinarians 2012: 1-6.

Gokce S, Bengib AO, Akinc E, Karacayd S, Sagdicc D, Kurkcue M, Gokce HS. Effect of hyperbaric oxygen during experimental tooth movement. The Angle Orthodontist 2008;78(2):304-8.

Hadi HA, Smerdon G, Fox SW. Osteoclastic resorptive capasity is suppresseed in patient receiving hyperbaric oxygen therapy. Acta Orthopaedica 2015;86(2):264-69.

Nilsson P, Albrektsson T, Granstrom G, Rockert HOE. The effect of hyperbaric oxygen treatmen on bone regeneration: an experimental study using the bone harvest chamber in the rabbit. JOMI on CD-ROM 1998. H. 43-8.

Wibowo A. Oksigen hiperbarik: terapi percepatan penyembuhan luka. Juke Unila 2015;5(9):124-6.

Mahdi H, Siswantoro S, Daniel H., Soepriyoto S, Setiawan, Michael H et al. Ilmu Kesehatan Penyelaman & Hiperbarik. Surabaya: Lakesla 2013. H. 295-314.

Jung S, Wermker K, Poetschik H, Ziebura T, Kleinheinz J. The impact of hyperbaric oxygen therapy on serological values of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Head & Face Medicine 2010;6(29):1-2.

Vezzani A, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Tersedia pada:https://www.ncbi.nlm.nih.gov/pubmed/21135885, Online. 2011 Jan;7(1):31-40.

Inokuchi T, Kawamoto T, Aoki K, Nagahama K, Baba Y, Suzuki S dll. The effects of hyperbaric oxygen on tooth movement into the regenerated area after distraction osteogenesis. Cleft palate-Craniofacial Journal 2010;47(4):382-92.

Tjandranegara F. Perbedaan jumlah osteoklas di daerah tekanan dan tarikan ligamen periodontal akibat pemberian terapi oksigen hiperbarik dan teripang emas (Stichopus hermanii) pada pergerakan gigi ortodonti. Skripsi Fakultas Kedokteran Gigi Universitas Hang Tuah 2017.

Haryanto FE. Perbedaan Jumlah Osteoblas di Daerah Tekanan Dan Tarikan Ligamen Periodontal Akibat Pemberian Terapi Oksigen Hiperbarik Dan Teripang Emas (Stichopus Hermanii) Pada Pergerakan Gigi Orthodonti. Skripsi Universitas Hang Tuah. 2017.

Andrade IJ, Taddei SRA, Souza PEA. Inflamation and tooth movement: The Role of Cytokines, Chemokines, & Growth Factors. Seminars in Orthodontics 2012;18(4):257-69.

Wijaya S, Prameswari N, Tandjung ML. Pengaruh pemberian gel teripang emas terhadap jumlah osteoklas di daerah tekanan pada remodeling tulang pergerakan gigi ortodonti. Denta Jurnal Kedokteran Gigi Universitas Hang Tuah Surabaya 2015;9(2):173-81.

Pelletier JM, Farran A, Montel E, Verges J, Pelletier JP. Discrepancies in composition and biological effects of different formulations of chondroitin sulfate. Molecules 2015;20:4277-89.

Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol 2009;6:988-995.

DOI: https://doi.org/10.24198/jkg.v29i3.15951